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InfDis of Skin and Eyes
Infectious Diseases of the Skin and Eyes
20
Microbiology
Undergraduate 2
11/30/2013

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Cards

Term
-trapped mass of sebum (oil) and dead cells clogging pores
-exaggerated keritinization in/around the follicle, blocking the pore
-overproduction of sebum when stimulated by hormones
pore close= whitehead
pore open but blocked with a dark plug of sebum= blackhead
vf: releases lipase to digest the oil surplus, resulting in intense local inflammation

what is it? CC? treatment?
Definition
acne caused by propionibacterium acnes, treated with face washing, topical antibiotics for large cases
Term
-highly contagious and includes fomites
-lesions usually around mouth/face, but can invovle extremeties
-causes the skin to flake or peel off
-appears as peeling skin, crusty/flaky scabs, honey-colored crusts

what is it? CC? treatment?
Definition
impetigo caused by staph aureus or strep pyogenes, treated topically with antibiotics
Term
-dermolytic condition, mostly in newborns and babies
-bullous lesions, desquamation of the skin
-appears as if dunked in boiling water
VF: exfoliative toxin

what is it? caused by? treated with?
Definition
Staphylococcal Scalded Skin Syndrome caused by Staph aureus, treated with handwashing and antibiotics to ensure it doesn't become systemic
Term
from punctures/introduction to deeper skin tissue - does not have to be obvious
-fast spreading infection in the dermis and subcutaneous tissues
-lymphangitis (red track lines)

treat with antibiotics (depending on gram-type or fungal)
Definition
cellulitis caused by staph aureus or strep pyogenes (gram +) or pesteurella multocida, bartonella henselae (gram -)
Term
deep skin necrosis, myonecrosis
-anaerobic cellulitis
VF: toxin mediated, anaerobic growth,spores
-diagnose from appearance (black and crunchy), smell (from buteric acid) and gram stain

treat with antibiotics and HBO2
what is it? CC?
Definition
gas gangrene caused by clostridium perfringens
Term
-endospores enter the skin through small cuts or abrasions
-papule that becomes increasingly necrotic then ruptures to form a black eschar

VF: glutamate capsule and 3 part toxin (PA-EF-LF)

-diagnosis: gram stain (G+ "bamboo rods" spores in culture, no spores in tissue
what is it? CC?
Definition
anthrax caused by bacillus anthracis
Term
-generally mild disease, can be life threatening in immunocompromised people
-fever, abundant rash on scalp, face and trunk
=lesions form macules (flat) and papules (risen) to itchy vesicles filled with clear fluid
-in several days they encrust and drop off

what is it? CC?
Definition
chicken pox caused by Varicella Zoster Virus or sometimes Herpes HHV-3
Term
virus enters sensory nerves and becomes latent then reemerges
-painful red rash lesions erupt on trunk across nerve lines
-may blister or crust and lasts months
CC: Varicella Zoster Virus
what is it?
Definition
Shingles
Term
sore throat, dry cough, runny nose, headache, conjunctivitis, lymphangitis, and fever, "Koplik's spots" in mouth
-highly contagious via aerosol
-rash erupts on head and then progresses to the trunk and extremeties until most of the body is covered
-spots appear then turn into red maculopapular, then coalesce
-can lead to encephalitis, pneumonia, or secondary infections

VF: causes syncytia
what is it? CC?
Definition
measles (also called rubeola) caused by measles virus (Helical RNA, morbilliviridae)
Term
-more macular and "milder" than classic Rubeola
-transmitted by respiratory or urine, but less contagious
-Fever, relatively minor rash disease with few complications except...
-hard to recognize in adults as rash may be mild or asymptomatic
-Teratogenic virus
-fetal injury varies depending on the time of infection (vascular, developmental, mitosis issues)
-test for (+) during pregnancy
-self-limiting
Definition
Rubella (German measles, 3 day measles)
Term
"slapped cheek disease"
-spreads on the body but is most prominent on arms, legs, and trunk - high contagion
-maculopapular, blotches run together (aka "lacy" rash)
-Can reoccur/exacerbate during stress
-self limiting

what is it? CC?
Definition
Fifth disease caused by Parvovirus B19
Term
-maculopapular rash common in babies & toddlers
-High fever followed by "blanching" rash
-Many cases proceed without the rash stage
-"3 day fever"
-By day 4, fever disappears and rash starts
-Rash often starts on trunk instead of head
*push on it, rash will go from white to red*

what is it? CC?
Definition
Roseola caused by Human Herpesvirus 6 & 7 (HHV-6/7)
Term
-Blistery rash common in toddlers (3-5 years)
-Mild malaise, fever and respiratory symptoms (runny nose, sore throat, etc) followed by a blistery rash 1-2 days later
-Most often starts with ulcerative lesions in mouth, then appears on palms and soles and other areas but not as frequent on trunk
-Lesions are often painful and look like popped blisters
-complications: dehydration (unable of swallow because of painful mouth sores), finger or toenail loss, 2 degree infection of open blisters, VERY rare meningitis or encephalitis

What is it? caused by? treated with?
Definition
Hand, Foot, and Mouth Disease (HFMD) caused by Coxsackievirus A16, it's self limiting.. treat symptoms
Term
-papular "pearl-like" lesions on skin
-Central core or plug of white, cheesy, or waxy material
-itching or scratching spreads it into "crops"
-affects children more than adults, adult versions are likely STD

what is it?
Definition
molluscum contagiosum
Term
-small scaly patches to severe inflammatory reaction to destruction of the skin
-confined to nonliving epidermal tissues
-all beginning with the word tinea

What is it? CC? treatment?
Definition
ringworm caused by dermatophytes, treated with Miconazole
Term
-long term fungal infection of the skin
-patches of discolored (reddish-tan) skin
-often has increased sweating and itching
-organism is related to dandruff cause
-can come from tanning beds that aren't cleaned properly

what is it? CC? treatment?
Definition
tinea versicolor caused by Malassezia furfur, treated with topical antifungals
Term
-an 'inbetween' skin and eye infection
-infection of the sebaceous or lacrimal glands near eye
-painful inflammation, often purulent
-can often progress to/result from conjunctivitis

what is it? CC? treatment?
Definition
stye often caused by staphylococcus aureus, treated with erythromycin (topically or optically) or by drainage
Term
-infection of the conjunctiva
-inflammation of the eye tissue and linings
-bacterial infections = usually milky discharge
-viral infections = usually clear exudate

what is it? 4 CC?
Definition
conjunctivitis usually caused by staph aureus, strep pyogenes, N. gonorrhoeae, or Chlamydias
Term
-infection of the cornea (more serious than conjunctivitis)
-begins almost identical to conjunctivitis
-invasion of deeper eye tissues occurs, can lead to complete corneal destruction
-"gritty" feeling in eye
-corneal clouding, vision deteriorations
-sharp pain and sensitivity to light, 'dendrite formation'
-as inf progresses, HSV deadens the corneal nerve, reducing pain but destroying the corneal surface

what is it? CC? treatment?
Definition
Keratitis caused by HSV-1, treated with aggressive corticosteroids + acyclovir or valacyclovir or Viroptic
Term
-infection of the epithelial cells of the eye
-starts with similar appearance to conjunctivitis + itching
-immune cell accumulation/inflammation, pebbled appearance
-eyelid scarring (white lines/bands/sheets w glistening or fibrous appearance)
-eventually lashes turn inwards and scrape off cornea (trichiasis) and dead cornea clouds
-major cause of blindness in certain parts of the world
-spread by fomites
Dx: lash postition

what is it? CC?
Definition
trachoma caused by chlamydia trachomatis type A, B, C
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