Term
| What is the MOA of Indirect Acting Cholinergic Agonists? |
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Definition
*Reversible inhibitors of Ach esterase at the NMJ, autonomic ganglia, cholingeric receptors at eh end organ
*Results in increase of Ach at the local receptor site |
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Term
| What Indirect Acting Cholinergic Agonist is used to distiguish between MG and CC in a Tensilon Test due to its short duration? |
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Definition
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Term
| List 4 Indirect Acting Cholinergic Agonists. |
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Definition
1. Edrophonium (10 min)
2. Physostigmine (2-4 hrs)
3. Neostigmine (2-4 hrs)
4. Pyridostigmine (4-6 hrs) |
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Term
| Indirect Acting Cholinergic Agonist used to treat Myasthenia Gravis, an autoimmune disease affecting skeletal muscle NMJ. It does so by prolonging and intensifying the actions of physiologically released Ach. |
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Definition
Pyridostigmine
*beneficial over others b/c of longer duration of effect |
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Term
| List 3 therapeudic of Indirect Acting Choline-esterase Inhibitors (Indirect Acting Cholinergic Agonists)? |
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Definition
1. MG
2. Reversal of neuromuscular blockers
3. Antidote for antimuscarinic toxicity |
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Term
| What are the Muscarinic side effects of Choline esterase inhibitors? |
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Definition
| salivation, urination, bradycardia, bronchoconstriction, abdominal cramping |
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Term
| What are the Nicotinic side effects of Choline esterase inhibitors? |
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Definition
| fasciculation (muscle twitch), and muscle cramping |
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Term
| What is a Cholinergic Crisis? |
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Definition
*Side effect/rare complication of high dose of Choline esterase inhibitor therapy
*presents as worsening MG
*based on Paradoxical Effect: continuous stimulation with ACh leads to premanent depolarization
* |
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