Macrophages in

• The lungs
• The liver
• The CNS

• Alveolar Macrophages
• Kupffer cells
• Microglia

↑ Neutrophils (PMN)

↓ Lymphocytes, monocytes, eosinophils, basophils

1. Ecosanoids/Arachidonic derivitives
2. Proteins (IL_{1, 2}, TNFα
3. Enzymes
4. Free radicals

SE of steroids

• Short
• Long

• Short: Nothing

• Long:

1. iatrogenic cushing's syndrome
2. Peptic ulcers
3. ↑ Infections
4. adrenal suppression
5. obesity/glucose intolerance

1. modify population of WBC
2. Inhibit Phos_A2 (no Arach release)

Cyclophosphamide

• MOA

• Prodrug
• Non-specific alkylating agent
• Inhibit signal 3

Azathioprine

MOA

• Antimetabolite
• Signal 3
• Affects adenosine deaminase

Methotrexate

MOA

• Inhibit dihydropholate reductase
• Signal 3

1. Cyclosporine
2. Muromonab-CD3

Cyclosporine

MOA

• inhibit calcineurin Phosphatases
• inhibit release of IL2
• Signal 1
• Nephrotoxic

Mycophenolate

MOA

• Inhibit Inosine monophosphate Dehydrogenase.  purine metabolism
• Signal 3

Muromonab-CD3

MOA

• Murine clonal antibody
• Blocks CD3
• Signal 1

Daclizumab

MOA

• Human IGg monoclonal AB
• IL-2 receptor inhibitor
• Signal 3 inhibition

Lymphocyte Immune Globulin

MOA

• Horse Immune Globulin
• T cell suppression
• Signal 1

• suppresses Immune response of Rh-negative individual to Rh-positive RBC
• Signal 1

Immune Globulin

MOA

• Passive immunity increased
• Signal 1
• for immunosuppressed patients

Interferon Gamma

• Activates WBC to produce more superoxide
• Treat Chronic gramulomatous disease

Which type of AB is involved in

Type 1 hypersensitivity

Type 2 hypersensitivity

Type 3 hypersensitivity

1. IGE
2. IGg & IGm
3. IGg & IGm
4. T cells

• NV
• Bone marrow suppression
• Hepatotoxicity
• renal,pulmonary
• Inhibition of B and T cell response