Term
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Definition
| in monocytes, they inhibit IL-1 production. thus inhibiting il-2 and IFN-gamma |
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Term
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Definition
| used for Autoimmune disorders: ITP, SLE, GN, AIHA, IBD |
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Term
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Definition
| SE: increased infections in elderly. osteoporosis, peptic ulcer |
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Term
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Definition
| Prodrug that is broken down into phosphoramide mustard and acrolein |
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Term
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Definition
| a metabolite of cyclophosphamide that alkylates DNA. |
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Term
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Definition
| SE: ***Hemorrhagic cystitis - caused by acrolein |
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Term
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Definition
Uses: Autoimmmune disorders: SLE, Factor XIII Ab, AIHA
DOES NOT prevent GvH reaction in transplants. |
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Term
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Definition
| calcineurin inhibitor. binds cyclophilin in Tcell. the complex binds calcineruin and dephosphorylates NFATC. causes decreased IL-2 syn. |
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Term
| cyclosporine and tacrolimus |
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Definition
| used with glucocorticoids |
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Term
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Definition
| Use: kidney, liver and cardiac allgenic transplants |
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Term
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Definition
| P-GP efflux and CYP3A4 METABOLISM decreases absorption of this immunosuppressant significantly |
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Term
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Definition
| SE: nephrotoxic and hepatotoxic, very little marrow suppression |
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Term
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Definition
inhibits IL-2 syn. same as cyclosporine, except it binds to FKBP-12.
Also 10-100x more potent than cyclosporine |
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Term
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Definition
| USE: liver and kidney rejections (along with glucocorticoids) |
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Term
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Definition
| Doesnt cause hirsutism or gingival hyperplasia, unlike cyclosporine. |
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Term
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Definition
uncompetitive inhibitor of IMP dehydrogenase. BLocks de novo synthesis formation of GMP
inhibits purine synthesis |
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Term
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Definition
| used for rescue therapy in kidney and liver transplants. Used in combo with prednisone |
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Term
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Definition
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Term
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Definition
| purine analog activated by HGPRTase, so ALLOPURINOL, a xanthine oxidase inhibitor, prolongs half life of this drug significantly |
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Term
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Definition
| Cytotoxic that only kills stimulated Tcells |
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Term
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Definition
| used for: crohns, MS, renal component of SLE, also kidney transplant |
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Term
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Definition
| SEs: marrow depression and blood problems |
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Term
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Definition
| cytotoxic pyrimidine inhibitor. |
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Term
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Definition
| M1 is the active metabolite that inhibits DHODH, which is a key enzyme in mitochondria that catalyzes key steps in de novo pyrimidine synthesis |
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Term
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Definition
| Uses: RHEUMATOID ARTHRITIS!!!!!, also renal and other organ transplants |
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Term
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Definition
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Term
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Definition
| Blocks IL-2 stimulated cell proliferation. MEch: complex with FKBP-12, which blocks mTOR. mTOR regulates cell growth |
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Term
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Definition
| USed in kidney and heart aloografts, as well as psoriasis and uveitis |
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Term
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Definition
| No nephrotoxicity, unlike Tacrolimus |
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Term
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Definition
| used in renal transplants with cyclosporine and corticosteroids. |
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Term
| Antilymphocyte and antithymocyte Abs. |
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Definition
| Very useful in GvH reactions and works in HvG. |
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Term
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Definition
| murine mab against CD3, just as the name says. |
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Term
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Definition
| reverses renal allograft rejection crisis |
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Term
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Definition
| Anti-CD52 Ab. CD52 is present on most lymphocytes, so this drug depletes tcells |
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Term
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Definition
| useful in combo with sirolimus in pts who cannot use steroids |
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Term
| Basiliximab and Daclizumab |
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Definition
| binds and blocks CD25 (IL-2aplha Receptor), competitively inhibits IL-2 mediated activation of T lymphocytes. |
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Term
| Basiliximab and Daclizumab |
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Definition
| allograft rejection - kidney |
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Term
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Definition
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Term
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Definition
| decoy for autoAb that attack myelin in MS |
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Term
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Definition
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Term
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Definition
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Term
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Definition
| SEVERE psoriasis, and RA, but also crohns |
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Term
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Definition
| Crohns, but also severe psoriasis and RA. |
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Term
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Definition
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Term
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Definition
| used for PSORIASIS**!!! TQ!! |
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Term
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Definition
| LFA-3/IgG1 fusion protein |
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Term
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Definition
| D antigen of RBCs AB, prevents erythroblastis fetalis and hemolytic disease of the newborn |
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