Term
| Anti-Nuclear Antibodies (ANA): |
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Definition
Present in most AI Dz, so ANA helps RULE IN AI Dz.
The normal titer of ANA is about 1:40 or less. Higher titers are indicative of an autoimmune disease |
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Term
| Anti-Double stranded DNA (native DNA antibody): |
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Definition
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Term
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Definition
| In conjuction with a positive anti-ANA, Rubin's state this is nearly pathognomonic for "SLE" |
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Term
| Anti-Phospholipid antibody (anti-Cardiolipin antibody): |
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Definition
SLE & others; In 1/3 of SLE pts
If encountered predisoses pts to thromboembolic complications
Stoke, Pulmonary Embolism, DVT |
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Term
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Definition
Drug-induced SLE
SHIPP - sulfonamides, hyralazine, isoniazid, procainamide, phenytoin (we don't need to know these drugs right now) |
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Term
| Rheumatoid Factor [An auto-antibody against the Fc portion of IgG(i.e. Anti-IgG)] |
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Definition
| Be aware that while Rheumatoid Factor is present in 80% of Rhemuatoid Arthritis Patients, it is not pathognomonic for RA...RF can be observed in Rheumatoid arthritis, Sjorgen's Syndrome, Chronic Hepatitis, Primary Biliary Cirrhosis, Any Chronic Viral infection, Bacterial Endocarditis, Leukemia, Dermatomyositis, Infectious Mononucleosis, Systemic Sclerosis (PSS) and SLE. |
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Term
| Anti SS-A (anti-Ro) and/or anti SS-B (anti-La): |
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Definition
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Term
| Anti DNA-topoisomerase I (anti-Scl-70): |
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Definition
| Scleroderma (Progressive Systemic Sclerosis, PSS) |
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Term
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Definition
| Scleroderma (CREST): CREST = Calcinosis in skin & elsewhere, Raynaud's phenomenon, Esophageal dysmotility from submucosal fibrosis, Sclerodactyly, Telangiectasia |
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Term
| Anti-histidyl-tRNA synthetase (Jo-1): |
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Definition
| Polymyositis & Dermatomyositis |
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Term
| Anti-U1 RNP (ribonucleoprotein): |
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Definition
| Mixed Connective Tissue Disease (MCTD) |
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Term
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Definition
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Term
| Anti-Microsomal, Anti-Thyroglobulin, &/or Anti-Thyroperoxidase antibody: |
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Definition
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Term
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Definition
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Term
| Anti-Glutamate decarboxylase: |
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Definition
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Term
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Definition
| Primary Biliary cirrhosis |
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Term
| Anti-Gliadin & Anti-Endomysial: |
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Definition
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Term
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Definition
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Term
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Definition
| Vasculitisis, Ulcerative colitis, Microscopic polyangiitis (usually negative in typical Polyarteritis Nodosa) Churg-Strauss, Rheumatoid arthritis, Primary sclerosing cholangitis (PSC), Focal necrotising and crescentic glomerulonephritis, |
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Term
| AL amyloid protein (derived from immunoglobulin light chain) |
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Definition
Primary Amyloidosis (immunocytic dyscaria)
In 5%-15% of patients with Multiple Myeloma |
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Term
| AA amyloid protein (derived from precursor Serum Amyloid A protein) |
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Definition
Secondary amyloidosis (reactive systemic)
Familial Mediterranean fever (similar distribution & type of amyloid as secondary amyloidosis) |
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Term
| Transthyretin amyloid protein |
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Definition
Portugese type of polyneuropathy (i.e. Familial Amyloid Polyneuropathy, i.e. Transthyretin Amyloidosis, i.e. Corino de Andrade's disease)
Senile Systemic Amyloidosis |
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Term
| A4 amyloid protein (or A-Beta protein) |
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Definition
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Term
| Amyloid protein derived from calcitonin |
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Definition
| Medullary carcinoma of the thyroid |
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Term
| Amylin (Islet amyloid polypeptide, IAPP) |
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Definition
| Insulin-resistant diabetes mellitus |
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Term
| Anti-Extractable Nuclear Antigen(ENA) |
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Definition
Mixed Connective Tissue Disease (MCTD)
Sjögren's syndrome
SLE
Scleroderma (Systemic and CREST). |
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Term
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Definition
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Term
| Anti-epithelial cell antibodies: |
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Definition
Pemphis vulgaris
Antibodies to Desmosomes |
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