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Immunopath: Autoantibodies, Amyloid proteins, and the like
These are the autoantibodies, amyloids, etc listed in Rubin's, WebPath, First Aid, & BRS Pathology. Let me know if I missed any or have any errors in these cards. Happy studying!
28
Pathology
Professional
05/17/2011

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Term
Anti-Nuclear Antibodies (ANA):
Definition
Present in most AI Dz, so ANA helps RULE IN AI Dz.
The normal titer of ANA is about 1:40 or less. Higher titers are indicative of an autoimmune disease
Term
Anti-Double stranded DNA (native DNA antibody):
Definition
SLE
Term
Anti-Smith:
Definition
In conjuction with a positive anti-ANA, Rubin's state this is nearly pathognomonic for "SLE"
Term
Anti-Phospholipid antibody (anti-Cardiolipin antibody):
Definition
SLE & others; In 1/3 of SLE pts
If encountered predisoses pts to thromboembolic complications
Stoke, Pulmonary Embolism, DVT
Term
Anti-Histone:
Definition
Drug-induced SLE
SHIPP - sulfonamides, hyralazine, isoniazid, procainamide, phenytoin (we don't need to know these drugs right now)
Term
Rheumatoid Factor [An auto-antibody against the Fc portion of IgG(i.e. Anti-IgG)]
Definition
Be aware that while Rheumatoid Factor is present in 80% of Rhemuatoid Arthritis Patients, it is not pathognomonic for RA...RF can be observed in Rheumatoid arthritis, Sjorgen's Syndrome, Chronic Hepatitis, Primary Biliary Cirrhosis, Any Chronic Viral infection, Bacterial Endocarditis, Leukemia, Dermatomyositis, Infectious Mononucleosis, Systemic Sclerosis (PSS) and SLE.
Term
Anti SS-A (anti-Ro) and/or anti SS-B (anti-La):
Definition
Sjogren's syndrome
Term
Anti DNA-topoisomerase I (anti-Scl-70):
Definition
Scleroderma (Progressive Systemic Sclerosis, PSS)
Term
Anti-Centromere:
Definition
Scleroderma (CREST): CREST = Calcinosis in skin & elsewhere, Raynaud's phenomenon, Esophageal dysmotility from submucosal fibrosis, Sclerodactyly, Telangiectasia
Term
Anti-histidyl-tRNA synthetase (Jo-1):
Definition
Polymyositis & Dermatomyositis
Term
Anti-U1 RNP (ribonucleoprotein):
Definition
Mixed Connective Tissue Disease (MCTD)
Term
Anti-Basement membrane:
Definition
Goodpasture's syndrome
Term
Anti-Microsomal, Anti-Thyroglobulin, &/or Anti-Thyroperoxidase antibody:
Definition
Hashimoto's thyroiditis
Term
Anti-Smooth muscle:
Definition
Autoimmune Hepatitis
Term
Anti-Glutamate decarboxylase:
Definition
Type I Diabetes Mellitus
Term
Anti-Mitochondrial:
Definition
Primary Biliary cirrhosis
Term
Anti-Gliadin & Anti-Endomysial:
Definition
Celiac disease
Term
c-ANCA:
Definition
Wegner's granulomatosis
Term
p-ANCA:
Definition
Vasculitisis, Ulcerative colitis, Microscopic polyangiitis (usually negative in typical Polyarteritis Nodosa) Churg-Strauss, Rheumatoid arthritis,  Primary sclerosing cholangitis (PSC), Focal necrotising and crescentic glomerulonephritis,
Term
AL amyloid protein (derived from immunoglobulin light chain)
Definition
Primary Amyloidosis (immunocytic dyscaria)
In 5%-15% of patients with Multiple Myeloma
Term
AA amyloid protein (derived from precursor Serum Amyloid A protein)
Definition
Secondary amyloidosis (reactive systemic)
Familial Mediterranean fever (similar distribution & type of amyloid as secondary amyloidosis)
Term
Transthyretin amyloid protein
Definition
Portugese type of polyneuropathy (i.e. Familial Amyloid Polyneuropathy, i.e. Transthyretin Amyloidosis, i.e. Corino de Andrade's disease)
Senile Systemic Amyloidosis
Term
A4 amyloid protein (or A-Beta protein)
Definition
Alzheimer disease
Term
Amyloid protein derived from calcitonin
Definition
Medullary carcinoma of the thyroid
Term
Amylin (Islet amyloid polypeptide, IAPP)
Definition
Insulin-resistant diabetes mellitus
Term
Anti-Extractable Nuclear Antigen(ENA)
Definition
Mixed Connective Tissue Disease (MCTD)
Sjögren's syndrome
SLE
Scleroderma (Systemic and CREST).
Term
Anti-Intrinsic Factor
Definition
Pernicious Anemia
Term
Anti-epithelial cell antibodies:
Definition
Pemphis vulgaris
Antibodies to Desmosomes
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