Term
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Definition
| agents that the body identifies as part of the body or as foreign |
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Term
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Definition
| always present, doesn't change, first response, non-specific, natural killer cells, granulocytes |
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Term
| Cluster of Differentiaion |
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Definition
All exist on the T cell surface
CD3- signals the Tcell of antigen presence |
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Term
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Definition
10-down regulates the immune response
12-upregulates the immune response
4- secreted by T cells and tells B cells to produce antibodies.
2- T-cell growth factor-adds more to the positive feedback loop
IFN-gamma- upregulates the immune response |
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Term
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Definition
Outside- TL 1,2,4,6
Inside-3,9 |
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Term
| Specific/adaptive Immune System |
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Definition
| response is specific to the antigen, memory, B cells, T cells, complement system |
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Term
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Definition
| type of granulocyte, part of the innate immune system, involved in allergies and parasitic infection |
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Term
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Definition
| granulocyte, involved in allergies and found in circulation |
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Term
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Definition
| granulocyte, used in allergies, found on the endotheliam of small blood vessels |
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Term
| Polymorphonuclear leukocyte (PMN) |
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Definition
| granulocyte, most predominant, short lived, ingest microbes and kill them using phagolysosomes, marginate-some found on the cell walls and some are found in circulatio. |
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Term
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Definition
| long lived, mature in the tissue spaces to become macrophages, ingest and kill bacteria using phagolysosomes,(APC) present antigen pieces as part of the MHC |
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Term
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Definition
| sophisticated and highly specialized type of macrophage |
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Term
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Definition
| large granular lymphocyte, detects and kills cancerous cells during infection, surveillance cell, has kill inhibitor receptor and upregulation receptor |
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Term
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Definition
| produces antibodies, involved in the adaptive immune response, formed in the bone marrow |
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Term
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Definition
| Involved in the adaptive immune response, must be involved to form memory, mature in the thymus |
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Term
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Definition
| secondary immune organ, drain tissue |
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Term
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Definition
| Secondary immune organ, red and white cells |
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Term
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Definition
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Term
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Definition
| alpha and beta, infected cells secrete interferons in order to warn other cells that they have been infected |
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Term
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Definition
| needs antibody to bind to antigen surface, uses IgM or IgG, cannot proceed without the binding of the antibody |
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Term
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Definition
| Does not need the antibody to be bound on the antigen, Begins when C3b is attached to the microbe surface, involves factors B and D |
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Term
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Definition
| Requires no antibody, uses mannose binding protein which acts like an antibody on the surface of the antigen, the pathway follows similiar to the classical complement. |
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Term
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Definition
| The coating of the microbe surface with molecules that will be recognized by the receptors on cells that need to kill it. Involves C3b |
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Term
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Definition
| mechanism used by PMNs and macrophages to find the site of infection, follow the concentration gradient created by cleaved pieces |
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Term
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Definition
| Smaller cleaved fragments which cause the mast cells and basophils to release their granules which leads to inflammation as macrophages enter tissue spaces |
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Term
| Membrane Attack Complex (MAC) |
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Definition
| C5bC6C7C8C9 fragment that is created during the complement cascade. The C9 is hydrophobic and punches a hole causing the cell to burst. |
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Term
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Definition
| First Antigen recognition, shortlived, not very rigorous, takes a few days |
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Term
| Secondary Immune Response |
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Definition
| After the antigen is presented following the first encounter, more vigorous, faster, longerlived |
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Term
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Definition
| Assist in the release of granules and histadine in the immune response de to allergies |
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Term
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Definition
| Glycoprotein that is the substrate for C1q involved in inflammation, Causes heart problems |
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