Term
| Name the 2 structures on cell surfaces of lymphocytes responsible for recognizing antigens. What are their function? |
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Definition
Membrane bound antibodies on B cells
T cell receptor on T Lymphocytes
Function: Detect external stimuli and trigger responses of the cells on which the receptors are expressed |
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Term
| Name things B lymphocytes recognize |
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Definition
Shapes
Conformations
native macromolecules ( proteins, lipids, carbohydrates, nucleic acids) |
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Term
| Name things T lymphocytes recognize |
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Definition
| Only peptides ( must be displayed by MHC on APC) |
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Term
| _________ is the collection of antigen receptors and signaling molecules in the B lymphocytes |
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Definition
| B cell receptor (BCR) complex is the collection of antigen receptors and signaling molecules in the B lymphocytes |
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Term
| Variable regions of T lymphocytes are made of what chains? |
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Definition
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Term
| Name the protein used for signaling by B cells and T cells |
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Definition
B cell: Proteins (Igα and Igβ) associated with membrane
Ig T cells:Proteins (CD3 and ζ) associated with TCR |
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Term
| When adjacent antigen receptors of lymphocytes bind to two or more antigen molecues, the recepotrs are pulled together into an aggregate; this is called |
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Definition
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Term
| Name the 2 functions in Humoral immunity |
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Definition
B cell membrane bound anitbodies recognize antigens to initiate humoral immune response
Secreted antibodies eliminate antigens in the effector phase of such response |
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Term
| Name the components of Antibodies |
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Definition
2 heavy and 2 light chains with one constand and one variable regions.
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Term
| What holds the chains together? |
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Definition
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Term
| OF the variable regions, what is the most variable? |
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Definition
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Term
| The different classes of antibodies are based on what? |
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Definition
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Term
| The parts of antigens that are recognized by antibodies are called __________ |
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Definition
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Term
| Lower the dissociation constant the ______ the affinity |
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Definition
| Lower the dissociation constant the higher the affinity |
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Term
IgE, IgG, IgD has has ____ antigin binding sites
IgA has _______antigin binding sites
IgM has ________antigin binding sites |
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Definition
IgE, IgG, IgD has has 2 antigin binding sites
IgA has 4 antigin binding sites
IgM has 10 antigin binding sites |
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Term
| Mucosal immunity, neonatal passive immunity is the function of |
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Definition
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Term
| Naive B Cell antigen receptor is the function of |
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Definition
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Term
| Mast cell activation ( immediate hypersensitity) is the function of |
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Definition
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Term
| Opsonization, complement activation, antibody dependent cell mediated cytotoxicity, neonatal immunity feedback inhibtion of B cells are a function of |
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Definition
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Term
| Naive B cell antigen receptor and complement activation are functions of IgM |
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Definition
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Term
| TCR with γδ recognize variety of protein and non proteins that are usually not displayed by _____. These are found in the ____ |
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Definition
TCR with γδ recognize variety of protein and non proteins that are usually not displayed by MHC
These are found in the epithelia |
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Term
| What do NK cells recognize? |
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Definition
| glycolipids and other non peptide antigens displayed by non polymorphic MHC like molecule |
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Term
| Which cell binds with a greater affinity? B or T? |
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Definition
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Term
| Name the 3 steps of lymphocyte maturation |
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Definition
1. Proliferation of immature cells
2. espression of antigen receptor genes
3. selection of lympocytes that express useful antigen receptors |
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Term
| Bone marrow and thymus secrete what to stimulate the proliferation of the earliest lymphocyte precursors? |
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Definition
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Term
| What is positive selection? |
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Definition
| Immature T cells are selected to recognize MHC molecules |
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Term
| What is negative selection? |
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Definition
| Immature B and T lymphocytes are selected agasint high affinity recognition of self antigens |
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Term
| What causes the diveristy of B and T lymphocytes? |
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Definition
| Antigen receptors are produced form several gene segments that are separate from one another in the germline and recombine during lymphocytes maturation |
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Term
| The commitment of lymphocytes progenitor to become a B lymphocyte is associated with |
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Definition
| recombination of one Ig V gene segment with one D and one J segment |
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