Term
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Definition
-specifically recognizes antigen
-Afferent func as B cell receptor
-Efferent biological functions
Produced by B cells. Part of Specific Immune System. 9 Classes of heavy chains IgG (1-4), IgA (1-2), IgE, IgD, IgM. 2 classes of light chains kappa and lambda. |
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Term
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Definition
| IgG (1-4), IgA (1-2), IgE, IgD, IgM. Have variable and 3 constant regions of 110 aa sequences each cysteine loops. Variable region contains V, D, J and assembled using the RAG enzyme. |
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Term
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Definition
| kappa and lambda. Have variable and constant regions of 110 aa sequences each cysteine loops. Variable region contains V and J assembled using the RAG enzyme. |
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Term
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Definition
-single antigen binding site
-produced by pepsin cleavage of Ig molecule |
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Definition
-fragment cystallizable
-produced by pepsin cleavage of Ig w/ papain
-heavy chain constant region |
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Term
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Definition
| Proline Rich Region between the Fab and Fc region of the Ab |
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Term
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Definition
-Associates with heavy and light chains
-it associate to have an exact # of monomer attached
-dimer in IgA, pentimer in IgM |
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Term
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Definition
-Covalently bonds to IgA in the lamina propria
-protects the IgA from harsh mucosal environment |
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Term
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Definition
-most predominant
-fixes complement
-4 classes
-1-most predominant
-2-not class the placenta
-3-short half life, 5 hinge region
-4-fixes complement |
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Term
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Definition
-monomer attached to B cell surface
-fixes complement
-pentimer-attached to J Chain |
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Definition
-2 types
-found in B cells located in the lamina propria
-found in monomers and dimers
-attaches to secretory piece |
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Term
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Definition
-no particular purpose
-found in pregnant woman right before birth
-found on B cell surface |
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Term
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Definition
-used in allergy response, coats basophils/mast cells for immune response
-Class 1 hypersensitivity |
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Term
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Definition
-diverse amino acid sequence/ tertiary structure determine specificity
-hyper variable regions - extensive amino acid diversity
-complemary determine regions |
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Term
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Definition
-very little amino acid difference within isotype
-determines bio func. of Ig molecules |
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Term
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Definition
-changes in the nucleotide sequence
-i.e. frameshift |
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Term
| hyper-variable (CDR/complementary determining region) |
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Definition
| -variable regions which have extensive amino acid diversity called CDR's which provide the majority of anitgen recognition |
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Term
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Definition
-regions in the Variable and Constant regions of Ab of about 110 aa.
-separated by cysteine loops. |
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Term
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Definition
| -an antigen have multiple determinants (epitopes) on the surface that can be used to secrete multiple types of antibodies in response |
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Term
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Definition
| -specifically recognize one antibody response by to an antigen |
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Term
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Definition
| -chooses the best possible antibody to a reintroduced antibody to have the best Antibody response |
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Term
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Definition
-types of heavy and light chain constant regions
-can be immunologically defined by antibodies produced |
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Definition
-minor A.A. variation in constant regions
-defined by antibodies produced against differences |
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Definition
-structural variations between Ig molecules of same isotype & allotype
-determined by variable region difference
-antibodies or anti-adiotypes are made against differences |
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Term
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Definition
| -action of the RAG enzyme with chops up the possible domains of Ab genes to create a finite number of Ab combination |
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Term
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Definition
| -the sloppy nature of the RAG, lipases, etc, which makes infinite possibilities for Ab diversity. |
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Term
| recombination activation gene (RAG) |
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Definition
| -chops up the possible domains of Ab genes to create a finite number of Ab combination. The sloppy nature of this enzyme leads to junctional diversity |
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Term
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Definition
| repeated exposure to the same antigen that continues to select receptor molecules which have very fine specificity and which bind the antigen |
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Term
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Definition
| -a part immunoglobulin diversity in which allows for infinite possibilities |
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Term
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Definition
| -picking a particular region of a gene and cutting out and excluding all other possibilities. This makes all Ab unique. |
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