Shared Flashcard Set

Details

Immunology
Step One Prep
7
Medical
Not Applicable
08/01/2008

Additional Medical Flashcards

 


 

Cards

Term
Cyclosporine

1. Mechanism
2. Use
3. Toxicity
Definition
1. Binds cyclophilins – Complex inhibits calcineurin – Blocks the differentiation and activation of T-cells – ? IL-2

2. Suppresses organ rejection, select autoimmune disorders

3. Viral infections, Lymphoma, Nephrotoxic (prevent with manitol dieresis)
Term
Tacrolimus (FK506)

1. Mechanism
2. Use
3. Toxicity
Definition
1. Mechanism
2. Use
3. Toxicity

1. Binds FK-binding protein – Complex inhibits calcineurin – Blocks the differentiation and activation of T-cells – ? IL-2

2. Suppresses organ rejection

3. Nephrotoxic, Peripheral Neuropathy, Hypertension, Pleural Effusion, Hyperglycemia
Term
Azathioprine

1. Mechanism
2. Use
3. Toxicity
Definition
1. Antimetabolite precursorof 6-mercaptopurine – Interferes with metabolism and synthesis of nucleic acids

2. Proliferating Lymphocytes, Kidney transplant, Autoimmune disorders (glomerulonephritis, hemolytic anemia)

3. Bone Marrow Suppression
Term
Muromonab-CD3 (OKT3)

1. Mechanism
2. Use
3. Toxicity
Definition
1.Monoclonal antibody to CD3 of T-cells – Blocks cellular interaction with CD3 – no T-cell signal transduction – Blocks Antigen recognition

2. Post-Kidney Transplant

3. Cytokine Release Syndrome, Hypersensitivity rxn.
Term
Sirolimus (Rapamycin)

1. Mechanism
2. Use
3. Toxicity
Definition
1. Binds to mTOR – Inhibits T-cell proliferation in response to IL-2

2. Post-Kidney Transplant in combo. w/ cyclosporine, corticosteroids

3. Hyperlipidemia, Thrombocytopenia, Leukopenia
Term
Mycophenolate Mofetil

1. Mechanism
2. Use
Definition
1. Inhibits de novo guanine synthesis – Blocks lymphocyte production

2. Immunosuppressant
Term
Daclizumab

1. Mechanism
2. Use
Definition
1. Monoclonal antibody to IL-2 receptor on T-cells

2. Immunosuppressant
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