Mechanism: inhibits IL-2 production by inhibiting calcineurin 

Use: suppresses organ rejection

Toxicity: nephrotoxic, predisposes to viral infections and lymphoma, gout

Mechanism: inhibits IL-2 secretion by binding FK-binding protein

Use: immunosuppression in organ transplants

Toxicity: nephrotoxic, peripheral neuropathy, hypertension, pleural effusion, hyperglycemia

Mechanism: inhibits T cell proliferation in response to IL-2 by inhibiting mTOR

use: immunosuppression after kidney transplant in combo with cyclosporine and steroids 

-also used in drug eluting stents

toxicity: hyperlipidemia, thrombocytopenia, leukopenia 

Mechanism: antibody that binds IL-2 receptor on T cells 

use: immunosuppression 

Mechanism: 6MP antagonist that interferes with nucleic acid synthesis, toxic to lymphocytes

use: kidney transplants, autoimmune disorders (glomerularnephritis and hemolytic anemia)

Toxicity: bone marrow suppression, increased toxicity with allopurinol use 

Mechanism: blocks CD3 signal transduction on T cells 

use: immunosuppression after kidney transplant 

toxicity: cytokine release syndrome, hypersensitivity reaction 

IL-2 recombinant cytokine

used in renal cell carcinoma and metastic melanoma treatment

-granulocyte colony stimulating factor

-used for recovery of bone marrow

-granulocyte-macrophage colony stimulating factor

-used for recovery of bone marrow 

-used in Hep B and C

-Kaposi's sarcoma

-Leukemias

-Malignant melanoma 

USES

-Multiple sclerosis treatment 

USES

-chronic granulomatous disease treatment 

-a therapeutic antibody targeting glycoprotein IIb/IIIa

-prevents cardiac ischemia in unstable angina and in patients treated with percutaneous coronary intervetion 

-targets erb-B2

-treatment used in HER-2 overexpressing breast cancer

-Targets CD20

-Treatment for B-cell non-Hodgkin's lymphoma 

-Targets IgE

-An additional line of treatment for severe asthma