Term
| What is the function of CD3? ζ? |
|
Definition
| Signal transduction by TCR |
|
|
Term
| What is the function of CD4? Ligand? Where is it expressed? |
|
Definition
Adhesion and signal transduction
Class 2 MHC
APC |
|
|
Term
| What is the function of CD8? Ligand? and where is it expressed? |
|
Definition
Adhesion and signal transduction
Class 1 MHC
APC, CTL target cells |
|
|
Term
| Name the fxn, ligand, and cell that express CD28 |
|
Definition
Co stimulation for signal transduction
B7-1/B7-2
APC |
|
|
Term
| Name the fxn, ligand and cell that express CTLA-4 |
|
Definition
Signal Transduction ( neg regulation)
B7-1/B7-2
APC |
|
|
Term
| Name the fxn, ligand and cell that express LFA-1 |
|
Definition
Adhesion
ICAM-1
APC, endothelium |
|
|
Term
| Name the fxn, ligand and cell that express VLA-4 |
|
Definition
Adhesion
VCAM-1
Endothelium |
|
|
Term
| Name the 3 things that make up the TCR complex |
|
Definition
|
|
Term
| What is the function of CD40? |
|
Definition
Activates APCs to express more B7 costimulators
Secrete cytokins like IL2,
enhance T cell differentiaiton |
|
|
Term
| What 2 cells secrete cytokins? |
|
Definition
|
|
Term
| What is the principle action and cellular source of IL-2? |
|
Definition
Principle Action: T cell growth and Stimulation
CD4 and 8 T cells |
|
|
Term
| What is the principle action and cellular source of IL-4? |
|
Definition
B cell switching to IgE CD4 T cells and mast cells
|
|
|
Term
| What is the principle action and cellular source of IL-5? |
|
Definition
Activation of Eosinophils
CD4 T cells, mast cells |
|
|
Term
| What is the principle action and cellular source of IFN y? |
|
Definition
Activation of macrophages
CD4 and 8 T cells, NK cells |
|
|
Term
| What is the principle action and cellular source of TGF β? |
|
Definition
inhibtion of t cell activation
CD4 T cells; many other cell types |
|
|
Term
| Whatis the most important cytokin produced by TH1 cell? |
|
Definition
|
|
Term
|
Definition
| activates phagocytes to kill ingested microbes and stimulates the production of antibodies that promote the ingestion of microbes by the phagocytes |
|
|
Term
| IL 12 promotes ___ and IL 4 prmotes _____ |
|
Definition
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