Term
| activates macrophages and Th1 |
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Definition
|
|
Term
|
Definition
|
|
Term
| has antiviral and anti tumor properties |
|
Definition
|
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Term
|
Definition
| CRP, complement, goaculation factors, ferritin |
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Term
|
Definition
|
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Term
|
Definition
| microbe surface molecules |
|
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Term
|
Definition
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Term
|
Definition
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Term
|
Definition
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Term
|
Definition
|
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Term
|
Definition
|
|
Term
| C1 esterase inhibitor and DAF fxn |
|
Definition
| prevent complement activation on self cells |
|
|
Term
| C1 esterase inhibitor deficiency |
|
Definition
| hereditary angioedem; ACEI CI in these pts |
|
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Term
|
Definition
| severe, recurrent pyogenic sinus and respiratory tract infections |
|
|
Term
| recurrent Neisseria bacteremia, complement deficiency |
|
Definition
|
|
Term
| complement deficiency with increased type III HSR |
|
Definition
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Term
|
Definition
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Term
|
Definition
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|
Term
| activates endothelial cells to express adhesion molecules |
|
Definition
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|
Term
| stimulates production of APP |
|
Definition
|
|
Term
| cytokine chemotactic factor |
|
Definition
|
|
Term
|
Definition
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Term
|
Definition
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Term
|
Definition
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|
Term
|
Definition
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|
Term
| leukocyte recruitment and vascular leak |
|
Definition
|
|
Term
| growth and differentiation of bone marrow |
|
Definition
|
|
Term
| cytokines secreted by macrophages |
|
Definition
| IL1, IL6, IL8, IL12 and TNF-alpha |
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Term
|
Definition
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|
Term
|
Definition
|
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Term
|
Definition
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Term
|
Definition
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|
Term
|
Definition
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|
Term
| promotes growth of B cells |
|
Definition
|
|
Term
| class switching to IgE and IgG |
|
Definition
|
|
Term
|
Definition
|
|
Term
| growth and differentiation of eosinophils |
|
Definition
|
|
Term
| modulates inflammatory response |
|
Definition
|
|
Term
|
Definition
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Term
|
Definition
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Term
|
Definition
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Term
|
Definition
| induce the production of a ribonuclease that inhibits viral protein synthesis by degrading viral mRNA |
|
|
Term
|
Definition
|
|
Term
|
Definition
| IgD, IgM, CD19-20, CD40, MHCII, B7 |
|
|
Term
| macrophage cell surface proteins |
|
Definition
| CD14, CD40, MHCII, B7, Fc and C3b receptors |
|
|
Term
|
Definition
|
|
Term
|
Definition
| self reactive t cells become nonreactive without cosimulatory molecule |
|
|
Term
|
Definition
| cross-link beta region of the T cell receptor to the MHC class II results in uncoordinated release of IFN-gamma from Th1 and subsequent release of IL1, IL6 and TNF-alpha from macrophages |
|
|
Term
|
Definition
| salmonella (2 flagellar variants), borrelia (relapsing fever), N gonorrhea (pilus protein), influenza, trypanosomes (programmed reaarrangement) |
|
|
Term
|
Definition
| preformed antibodies, rapid onset, short span, ex IgA in breaks milk, antitoxin RSV monoclonal Ab |
|
|
Term
|
Definition
| exposure to foreign Ag, slow onset, long-lasting, natural infection, vaccines, toxoid |
|
|
Term
|
Definition
| microorganisms los pathogenicity but retains capacity for transient growth within inoculated host; cellular respone |
|
|
Term
| pros and cons of live attenuated |
|
Definition
pro= stronga dn life-long immunity
con = may revert to virulent form |
|
|
Term
| live attenuated vaccine examples |
|
Definition
| measles, mumps, polio (sabin), rubella, varicella, yellow fever, intranasal flu |
|
|
Term
| inactivated/killed vaccine |
|
Definition
| pathogen is inactivated; maintaining epitope structure on surface Ag is important for immune respond; humoral immunity |
|
|
Term
| pros and cons of inactivated vaccines |
|
Definition
pro = stable and safer
con = weaker immune respone, need boosters |
|
|
Term
| examples of inactivated vaccines |
|
Definition
| cholera, influenza, hep A, polio (salk) rabies |
|
|
Term
|
Definition
| anaphylactic and atopic, free Ag cross-linked IgE on made cell -> vasoactive amines act at post capillary venues, develops rapidly |
|
|
Term
|
Definition
1- opsonize or activated by C'
2- Ab recruit Nt and macrophages
3- bind cell receptor and inhibit function |
|
|
Term
|
Definition
| immense complexes acitvate complement which attract neutrophis which release lysosomal enzymes |
|
|
Term
|
Definition
| type III in which ab to the foreign proteins are produced. IC form and are deposited in membranes where they fix complement |
|
|
Term
|
Definition
| local type III; intradermal injection of Ag induces ab which form ag-ab complexes in the skin; edema, necrosis and activation of complement |
|
|
Term
|
Definition
| delayed type; t cells encounter Ag and then release lymphokines |
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|
Term
|
Definition
|
|
Term
|
Definition
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|
Term
|
Definition
|
|
Term
|
Definition
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|
Term
|
Definition
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|
Term
|
Definition
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|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| acute hemolytic transfusion reations |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
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|
Term
|
Definition
|
|
Term
|
Definition
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|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| hypersensitiviey pneumonitis |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| type I HSR against plasma proteins in transfused blood |
|
|
Term
| blood anaphylactic reaction |
|
Definition
| severe reaction, IgA deficient individuals must receive blood products that lack IgA |
|
|
Term
|
Definition
| type II HSR; host Ab against donor HLA ag and leukocytes |
|
|
Term
|
Definition
| type II hsr, intravascular hemolysis. ABO blood group incompatibility or extravascular hemolysis |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| primary sclerosing cholangitis |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| polymyositis and dermatomyositis |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| anti-glutamate decarboxylase |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| Churg-straus, microscopic polyangitis |
|
|
Term
|
Definition
|
|
Term
|
Definition
| pauci immune crescentric GN |
|
|
Term
|
Definition
|
|
Term
| infections with no T cells |
|
Definition
| sepsis, CMV, EBV, VZV, resp/gi viruses, condida, PCP |
|
|
Term
| infections with no B cells |
|
Definition
| encapsulated (SSHiNN), enteroviral encephalitis, polio, GI giardiasis |
|
|
Term
| infections if no granulocytes |
|
Definition
| staph, psuedomoas, candida, ocardia, aspergillus |
|
|
Term
| infection with no complement |
|
Definition
|
|
Term
|
Definition
| BTK = tyr kinase gene -> blocks pro-B -> pre-B |
|
|
Term
|
Definition
| recurrent bacterial infections after 6 months |
|
|
Term
|
Definition
| normal pro-B, decreased number of B cells, Decreased Ig |
|
|
Term
hyper-IgM
- defect
- presentaiton
- labs |
|
Definition
- defective CD40L on Th cells, can't class switch
- severe pyogenic infections
- increased IgM, decreased other Ab |
|
|
Term
Chronic mucocutaneous candidiasis
- defect
- presentation |
|
Definition
- T cell dysfunction
- candida infections on skin and mucus membranes |
|
|
Term
SCID
- defect
- presentation
- labs |
|
Definition
- IL-2R defect, Adenosine deaminase deficiency; failure to synthesize MHCII
- recurrent viral, bacterial fungal and protozoal; no thymic shadow, no germinal centers,
- decreased IL2R -> decreased T cell activation
increased adenosine -> toxic to B and T cells |
|
|
Term
CVID
- defect
- presentation
- labs |
|
Definition
- B cell maturation, many causes
- can be acquired in 20s-30s, increased risk of autoimmune disease, lymphoma, sinopulmonary infections
- normal B cells, decreased plasma cells and Ig |
|
|
Term
Ataxia telangiectasion
- defect
- presentaiton
- labs |
|
Definition
- ATM gene which codes for DNA repair
- ataxia, spider angiomas, IgA deficiency
- decreased IgA |
|
|
Term
Wiskott-Aldrich
- defect
- presentaiton
- labs |
|
Definition
- X-linked recessive defect, progressive deletion of B and T
-WA Immunodeficiency, Thrombocytopenia, Eczema, Recurrent infections |
|
|
Term
Digeroge
- defect
- presentaiton
- labs |
|
Definition
- 22q11 deletion; failure of 3rd and 4th pharyngeal pouches
- hypocalcemia, recurrent viral/funcal infetions, heart and great vessel abnormalities
- decreased T cells, Decreased PTH, decreased Ca; absent thymic shadow on CXR |
|
|
Term
LAD
- defect
- presentation
- labs |
|
Definition
- LFA-1 on phagocytes
- delayds separation of umbilicus
- neutrophilia |
|
|
Term
chediak higashi
- defect
- presentation |
|
Definition
- AR, defect in LYST; microtubule dysfunction
- recurrent pyogenic infection, partial albinism, peripheral neuropathy |
|
|
Term
IL-12 receptor deficiency
- defect
- presentation
- labs |
|
Definition
- decreased Th1
- mycobacterial infections
- decreased IFN-gamma |
|
|
Term
Hyper-IgE syndrome
- defect
- presentation
- labs |
|
Definition
- failure to prdoce IFN-gamma and Nt can't respond to chemotactic stimuli
- coarse facies, staph abscesses, retained primary teeth, increased IgE, Dermatologic (eczema)
- increased IgE |
|
|
Term
CGD
- defect
- presentation
- labs |
|
Definition
- lack NADPH oxidase
- catalase positive organisms
- negative NBT test |
|
|
Term
- autograft
- syngenetic graft
- allograft
- enograft |
|
Definition
- from self
- identical twin or clone
- nonidnetical individual of same species
- xenograft |
|
|
Term
hyperacute transplant rejection
- onset
-pathogenesis
- features |
|
Definition
- within minutes
- Type II due to presence of preformed anti-donor Ab
- occlude graft vessels, causing ischemia and necrosis |
|
|
Term
transplant rejection acute
- onset
- pathogenesis
- features |
|
Definition
- weeks
- cell mediated due to CTLs reacting against foreign MHCs; reversible with immnosuppressants
- dense interstitial lymphocytic infiltrates |
|
|
Term
transplant rejection chronic
- onset
- pathogenesis
- features |
|
Definition
- months to years
- MHCI-nonself is perceived as MHCI-self presenting a non self Ag
- irreversible; vascular damage, fibrosis of graft tissue and blood vessels |
|
|
Term
graft vs. host
- onset
- pathogenesis
- features |
|
Definition
- varies
- grafted immunocompetent T cells proliferate in irradiated immunocompromised host and reject cells with 'foreign" particles leading to organ dysfunction
- maculopapular rach, jaundice, hepatosplenomegaly and diarrhea |
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|
