Term
| no memory, fast, nonspecific |
|
Definition
|
|
Term
| Nt, macrophages, dendritic, NK, and complement |
|
Definition
|
|
Term
|
Definition
|
|
Term
| slow at first but memory is faster and more robust |
|
Definition
|
|
Term
| t cells, b cells and circulating Ab |
|
Definition
|
|
Term
|
Definition
|
|
Term
| MHC for intracellular peptides |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| MHC expressed on all nucleated cells |
|
Definition
|
|
Term
|
Definition
|
|
Term
| MHC that binds TCR and CD4 |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| psoriatic arthritis, ankylosing spondylitis, inflammatory bowel, reiter's |
|
|
Term
|
Definition
|
|
Term
|
Definition
| MS, hay fever, SLE, goodpastures |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| pernicious anemia, hashimoto's |
|
|
Term
|
Definition
| steroid responsive nephrotic syndrome |
|
|
Term
| uses perforin and granzyme in innate |
|
Definition
|
|
Term
| cytokines that enhance NK cells |
|
Definition
| IL12, IFN-beta, IFN-alpha |
|
|
Term
|
Definition
1- nonspecific activation signal on target cell
2- absence of MHCI on target cell surface |
|
|
Term
|
Definition
|
|
Term
| T cell differentiation in thymus |
|
Definition
| at corticomedullary junction |
|
|
Term
| positive selection in thymus |
|
Definition
|
|
Term
| negative selection in thymus |
|
Definition
| corticomedullary junction |
|
|
Term
|
Definition
1- MHCII with TCR
2- B7 with CD28 |
|
|
Term
|
Definition
1- MHCI and TCR
2- IL2 from Th |
|
|
Term
| B cell activation signals |
|
Definition
1- IL4, IL5 IL6 from Th2
2- CD40 with CD40L |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| virus-infected, neoplastic and donor graft cells |
|
|
Term
|
Definition
| perforin and granzyme -> induce apoptosis |
|
|
Term
| Regulatory T cells express |
|
Definition
|
|
Term
| Treg produce what cytokines? |
|
Definition
|
|
Term
|
Definition
| suppress CD4 and CD9 t cell effector functions |
|
|
Term
|
Definition
| make Ag, allergy, type II and III HSR, hyperacute organ rejection |
|
|
Term
|
Definition
CD4 = helps B cells
CD8 = kill virus infected cells
Type IV HSR, acut and chronic organ rejection |
|
|
Term
|
Definition
| antigen-binding fragment; only 1 antigenic specificity per B cell |
|
|
Term
|
Definition
| constant, carboxy terminal, complement binding, carbohydrate side chaings, determines isotype |
|
|
Term
|
Definition
|
|
Term
| how is ab diversity generated? |
|
Definition
| random recombination of VJ and VDJ genes, random combination of heavy chains with light chains, somatic hypermutation, addition of nucleotides to DNA during recombination by terminal deoxynucleotidyl transferase |
|
|
Term
| activation of recombination of VDJ |
|
Definition
|
|
Term
| main ab in 2' response to Ag |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| neutralizes toxins and viruses |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| binds mast cells and basophils |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| lack a peptide component, (LPS and polysaccharide capsular Ag) can't be presented to T cells; stimulates IgM, no memory |
|
|
Term
|
Definition
| ag contianint a protein component (conjugated H. influenzae); class switching occurs |
|
|
