Term
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Definition
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Term
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Definition
Peptidoglycan (gram +)
bacterial lipoproteins
non conventional LPS
ZYMOSAN (FUNGI)
GPI-anchored glycoproteins (protozoans) |
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Term
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Definition
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Term
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Definition
| Unmethylated CpG DNA (bac and viruses) |
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Term
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Definition
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Term
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Definition
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Term
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Definition
| G-rich oligonucleotides (viruses) |
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Term
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Definition
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Term
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Definition
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Term
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Definition
- produced by virally infected cells
- induced by dsRNA and long (polycistronic RNA) |
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Term
| Phenotypic changes in infected cells |
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Definition
- low MHC I then ^^
- ^^ IFN-a/B & IFNAR expression
- ^ Fas
- ^ Pkr
- ^ 2,5 OAS/Rnase L expression |
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Term
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Definition
- most Ig in blood
- crosses placenta
- fixes complement |
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Term
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Definition
- colostrum, resp and intestinal mucous, saliva, tears
- J joining polypeptide chains |
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Term
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Definition
- Pentamer
- 1st to appear in ontogeny
- 1st to appear in response to antigen stimulation |
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Term
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Definition
| - serves as a receptor on the B-cell surface |
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Term
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Definition
Fc region that binds mast cells
involved in allergic reactions |
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Term
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Definition
- From macros
- endogenous pyrogen= fever and acute inflammation
- activates endothelium to express adhesion molecules
- induces chemokine secretion to recruit leukocytes |
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Term
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Definition
- From Th1
-Stimulates growth of helper and cytotoxic t-cells |
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Term
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Definition
- Secreted by all Tcells
- supports the growth and differentiation of bone marrow stem cells. functions like GM-CSF |
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Term
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Definition
- From Th2
- induces differentiation into Th2
- promotes growth of B-cells
- enhances class switching to IgE,IgG |
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Term
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Definition
- from th2
-promotes differentiation of Bcell
- enhaces class switching to IgA
- Stimulates the growth and diff of eosinophils |
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Term
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Definition
- From macros
- endogenous pyrogens
- fever and production of acute phase proteins |
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Term
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Definition
- From macros
-Major chemotactic factor for neutrophils |
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Term
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Definition
- From reg Tcells, Th2
- Modulates inflammatory response
- Inhibits Tcell, Th1
- Activates Th2
- TGF-B has similar action |
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Term
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Definition
- From macros and B cells
- induces differentiation of T cells into Th1
- activates NK cells |
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Term
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Definition
- from bone marrow
- stimulates pre-Bcell and pre-tcells |
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Term
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Definition
- from Th-cells
- t-cell mitogen |
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Term
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Definition
- from bone marrow
- stimulates hematopoeisis
- enhances acute phase protein synthesis |
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Term
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Definition
- from Th2 cells
- inhibits inflammatory cytokines |
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Term
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Definition
-from tcells
- enhances growth of intestinal epithelium
- tcell mitogen |
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Term
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Definition
-from macros
- mediates septic shock
- Activates endothelium
- causes leukocyte recruitment, vascular leak |
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Term
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Definition
- from Th1
- activates macros and Th1
- supresses Th2
- ^^ MHC I, II in all cells |
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Term
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Definition
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Term
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Definition
TCR (binds MHC,antigen)
CD3 (signal transduction)
CD28 (binds B7 on APC)
CD4 or CD8 |
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Term
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Definition
Ig
CD19,CD20,CD21,CD40
MHC II
B7 |
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Term
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Definition
CD14, CD40
MHC II,
B7
Fc & C3b receptors (enhances phagocytosis) |
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Term
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Definition
CD16 (binds Fc of IgG)
CD56 (unique marker |
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Term
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Definition
signal 1: MHC II from APC---> TCR
signal 2: B7---> CD28 |
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Term
| Cytotoxic T-cell activation |
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Definition
signal 1: MHC I
signal 2: IL-2 from Th |
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Term
| B-cell activation and class switching |
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Definition
MHC II, activates Th2-cell
signal 1: IL-4,5,6 from Th2
signal 2: CD40 on Bcell binds CD40L
costimulatory: B7, CD28 |
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Term
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Definition
- cell mediated vs humoral
- IL-2, IFN-y vs IL-4,5,10
- Activates: macros, CD8 vs Bcells(IgE)
- inhibited By: IL-10 vs IFN-y |
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