Term
| What is the extrinsic vs intrinsic caspase? |
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Definition
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Term
| What are the two methods of CTL killing? |
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Definition
-Fas ligand/Fas death receptor (extrinsic)
-Granule release containing perforin and granzyme which work together
-Perforin makes pores while granzyme enters and activates caspases (starts at Bid to tBid) |
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Term
| How do NK cells detect cells for apoptosis? What is the receptor on the NK called? |
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Definition
-They look for missing MHC 1
-Doesn't matter what is presented, just number
-Called KIR kill-cell Ig-like receptor |
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Term
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Definition
-Activation induced cell death
-The cell death process starts when these immune cells are activated so that they don't persist for too long |
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Term
| What is the role of IL-2 in cell death? |
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Definition
| -Activates naive T cells and starts the process toward death |
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Term
| What is expressed in resting but not activated T cells that usually prevents death? |
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Definition
-C-FLIP (caspase inhibitor)
-Degraded what T cell is activated |
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