Term
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Definition
-Colony stimulating factor
-A growth factor
-Can be M-CSF (macrophage), G-CSF (granulocyte), or MG-CSF
-EPO (erythropoietin) is for RBC development
-IL-3 promotes myeloid progenitor growth from stem cell |
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Term
| What are the markers for immature, mature, and activated T cells? |
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Definition
-CD3 for all T cells
-CD4 or CD8 for mature, also usually CD28
-CD25 for activated (the IL-2 receptor) |
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Term
| What is the name for immature T cells and where would we find them in the thymus? |
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Definition
-Called thermocytes, and we would find them in the cortex
-Called double negative or double positive depending on whether they express CD4 & 8 or not |
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Term
| What are Th1 and Th2 cells? What's their MHC? How common are Th cells? |
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Definition
-1 is involved in inflammation and activates CTLs (cell-mediated response)
-2 is involved in the humoral response and activates B cells
-Th cells use MHC class II and have CD4
-Th cells comprise over half of blood lymphocytes |
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Term
| What are the cell signals for T cells to go from naive to immature effector to Th1 & 2? |
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Definition
-IL-2 stimulates proliferation to immature effector (Th0 cells)
-IFN-γ & IL-12 take it to Th1
-IL-4 takes it to Th2 |
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Term
| What are CD4 T regulatory cells? |
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Definition
-They secrete IL-10 and TGF-β (transforming growth factor β) to suppress immune response
-Helps fight autoimmunity |
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Term
| What do cytotoxic T cells secrete? Abundance? |
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Definition
-IFN-γ
-Remember, this activates and is produced by NK cells
-It also activates macrophages (remember that macrophages can be activated enhancing their action)
-About 20-25% of blood lymphocytes |
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Term
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Definition
|
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Term
| How do we assess ability of lymphocyte cells to proliferate? |
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Definition
-Phytohemagglutinin or Concanavalin (PHA or ConA) for T cells
-Pokeweed mitogen (PWM) for both
-Epstein Barr virus (EBV) for Bcells |
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Term
| What are the most potent presenting cells and why? Where do they hang out? |
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Definition
-Dendritic cells because they have many MHCII proteins
-Mostly in the lymph nodes and spleen |
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