Term
| alternate pathway of complement |
|
Definition
uses C3bBb
constituitively active |
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Term
|
Definition
C4bC2a mannose binds lecitin to mannose agar
MBK activates a protesae whic cleaves C4 and C2 generatign a C3 convertase which leads to C3b accumulation on microbe surface. |
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Term
|
Definition
not consti active
antibody mediated. |
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Term
| draw alternate and classical pathway |
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Definition
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Term
|
Definition
| IgE receptor on a mast cell |
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Term
|
Definition
| antibody that binds to FcE on the mast cell |
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Term
| antigens bind to the _____ which is boud to the mast cell |
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Definition
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Term
|
Definition
| stabilized the C3b in the alternative pathway |
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Term
|
Definition
| CR1 takes the antigen antibody complex and cleans it fromthe blood by pulling on the rbc medaites phagocytocis |
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Term
|
Definition
| serum marker for systemic infection |
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Term
|
Definition
mediator: IgE
time course: hours and minutes
ex: bee sting |
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Term
|
Definition
mediator: antibody against surface
time course:chronic
example: pemhigus vulgaris
myesthenia gravis-Ach receptor
graves disease-TSH activator |
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Term
| type III hypersensitivity |
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Definition
mediator: antibodies against circulating antigens
Systemic Lupus
srum sickness |
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Term
|
Definition
t cells mediated
weeks
contact dermatitits |
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Term
|
Definition
| Ige mediated type I hypersensitivity |
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Term
|
Definition
| not IgE direct degranulation-drugs can do this |
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|
Term
| immediate treatment for anaphylactic or anaphylactoid shock |
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Definition
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Term
|
Definition
realease of histamine from mast cells upon degranulation
brachoconstriction/edema
drop in blood pressure |
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Term
|
Definition
pccurs later when aeosinophils/lymphocytes are recruited
corticosteroid treatment |
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Term
| immunodeficiency of t cells |
|
Definition
| chronic infection of intracellular pathogens |
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Term
|
Definition
chronic sinopulmomnary infection
CNS complications from enteroviral infections |
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Term
| Complement immunity malfiction |
|
Definition
s. pneumoniae
n. meningitides
h. influenzae |
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Term
|
Definition
| can't form pus or pus doesn't kill |
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Term
|
Definition
| bactermia and trouble with capsulated bacteria |
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Term
|
Definition
| deficiency of common gamma chain or a problem with RAG, artemis enzymes. |
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Term
|
Definition
cytoskeletal defect
thrombocytopemia |
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Term
|
Definition
|
|
Term
| X linked a gammaglobluinemia |
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Definition
|
|
Term
| common variable deficiency |
|
Definition
| can't produce antibodies. |
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Term
|
Definition
| leukocyte adhesion defect- no pus neutrophils and monocytes cant attch due to defect in IAm. |
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Term
|
Definition
| common granulomatous disease |
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