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Immunology Problem Set 3
TA Handout 3
23
Medical
Professional
03/08/2009

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Cards

Term
Explain the 4 life phases of a B cell
Definition
B cells are generated in the bone marrow

elimate self reactive b cells in bone marrow

activation of B cells by foreign antigen in secondary lymphoid tissue

differentiation to antibody secreting plasma cells and memory cells in secondary lymphoid tissues.
Term
stem cell heavy and light chains
Definition
germline germline
Term
order of b cell
Definition
heavy chain light chain
early pro b dj germ
late pro b VDJ germ
large pre b VDJ delta 5 v pre B
this temporay light chain helps with allelic exclusion, proliferation, initiates light chain and K/D

small pre b VDJ germ
immature pre b IgM tryout
mature naive b
Term
Which poriton of the antibody determines the Ig isotype?
Definition
the constant region
Term
directly binds the antigen
Definition
variable region
Term
bound by the effector cell receptor
Definition
the constant region
Term
Contains complementarity determining region
Definition
The variable region
Term
contains disulfide bridges
Definition
all parts of the ig
Term
Fc region
Definition
determines effector function
Term
isotype
Definition
different type of Fc regiond etermines the type of immunoglobulin you have. the heavy chain sets the type
Term
Epitope
Definition
part of the antigen that is bound by the Ig
Term
Idiotype
Definition
Part of the antibody that binds the antigen
Term
CD19
Definition
B cell signaling receptor
Term
CR2 (cd 21)
Definition
complement receptor
Term
B cells need survivial signals expressed by _______
Definition
follicular dendritic cells.
Term
in order to home, b cells must express
Definition
CXCR5
Term
TI-1
Definition
tlr
Term
TI2
Definition
Polymer recognition
Term
the story of b cell activation
Definition
1) naive b cell into t cell zone
2) b cell interacts with cd4 t cell and becomes activated and begins to proliferate
3) a subset of activated b cels migrates to gernmi cal centers in the the cortex draggin their cd 4 cell with them.
4) class switch remobine
5) fds pay attention to some in the germinal center-promote survival
6) plasma and memory cells exit the germical center.
Term
Ig M
Definition
multimeric 5 er bounded by J chain
very good at fixing complemenmt
low afinity
Term
Ig G
Definition
non multimeric brambell receptor crosses the placenta.

most b cells class switch to IgG. long term memory
monomeric
leaks out _> brambell receptor brins back
vasolateral transport process long half lip placenta crosses
Term
IgE
Definition
not multimeric structurally same as IgG
foudn in serum
allergic response
Term
IgA
Definition
mucosal sufraces
mucosal immunity
poly IgA receptor blood to mucous
foudn in blood
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