Term
Which of the following does not originate from myeloid progenitor cells?
Basophil, eosinophil, erythrocyte, Mast cell, NK cell, neutrophil, platelet |
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Definition
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Term
| Which interleukin stimulates lymphoid cell development in the bone marrow? |
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Definition
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Term
| Which IL stimulates myeloid cell development |
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Definition
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Term
| Which IL has a a role in stimulation of eosinophil production in the bone marrow? |
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Definition
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Term
| a macrophage is the end cell of which line of differentiation |
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Definition
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Term
Which of the following cells is most critically involved which antigen transport?
Dendritic cell, granulocyte, macrophage, monocyte,neutrophil |
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Definition
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Term
| Where is the idiotype of an antigen-recognition molecule located? |
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Definition
| in the amino-terminal domains |
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Term
| The amino acid sequence of the antigen-recognition molecule constant domains determines what? |
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Definition
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Term
| what is the signal transduction molecule of the T-lymphocyte? |
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Definition
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Term
| Which of the following is unique to B-cell antigen receptor formation |
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Definition
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Term
Which of the following statements is true of a hapten?
-It is a single epitope
-it is a thymus-dependent antigen
-it is a thymus-independent antigen
-it is an idiotype
-it is an immunogen |
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Definition
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Term
| What mediates the tight binding between leukocytes and endothelium to promote transendothelial migration into areas of injury |
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Definition
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Term
| When a tissue is damaged, white blood cells are attracted to the area by chemoattractive molecules released in the area. what is the origin of formyl methionine peptides generated in this way? |
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Definition
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Term
| Following phagocytosis, ingested particles are digested intracellularly as a result of three overlapping killing mechanisms. How is hypochlorite generated inside the phagolysosome? |
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Definition
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Term
| A patient has a deficiency of CD18. What is the most likely dx? |
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Definition
| Leukocyte adhesion deficiency |
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Term
| What is the term for the molecule that prevents the binding of normal cellular peptides to the MHC class II molecule? |
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Definition
| invariant chain...Blocks the peptide groove of the MHC class II molecule to prevent any peptide binding until the molecule is added to the phagolysosomal vesicle |
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Term
| How do superantigens cause systemic toxicity? |
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Definition
| By activating T-cells polyclonally |
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Term
| What is the cytokine produced by the T-helper 1 cell that inhibits the proliferation of TH2 cells |
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Definition
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Term
Which of the following condition would be made less serious by stimulation of the Treg cell?
-autoimmune disease
-bacterial infection
-Cancer
-Hypersensitivity disease
-virus infection |
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Definition
autoimmune disease
Treg cells produce IL-10 and are believed to play a role in decreasing autoimmune disease |
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Term
| What is the difference between thymus-dependent and thymus-independent antigens |
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Definition
| thymus-dependent antigens contain peptides |
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Term
| What is the result of somatic hypermutation followed by clonal selection |
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Definition
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Term
| What interaction is most unique in inducing isotype switching |
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Definition
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Term
Which of the following statments concerning IgM is true?
-it acts as an opsonin
-it has the highest avidity of any immunoglobulin
-it has the highest serum concentration
-it is the antigen receptor of memory Bcells
-it mediates antibody-dependent, cell mediated cytotoxicity
- |
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Definition
| It has the highest avidity of any immunoglobulin |
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Term
| What do IgA and IgM have in common? |
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Definition
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Term
| What is the portion of IgA on the mucosal surface that functions in transepithelial transport and protection from proteolytic cleavage |
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Definition
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Term
| Which cytokines is most important in the isotype switch to IgA synthesis? |
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Definition
| IL-5; TGF-beta also required |
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Term
| Which cytokines is most important in the isotype switch to IgE synthesis? |
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Definition
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Term
| What is the cell responsible for stimulation of cell-mediated immune responses? |
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Definition
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Term
| What molecule must be present on the surface of a cell for it to be able to perfom antibody-dependent, cell-mediated cytotoxicity? |
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Definition
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Term
| How do NK cells and cytotoxice T cells induce pores in the membrane in the membrane of their target cells? |
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Definition
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Term
| A mixture of peripheral blood leukocytes from a virus infected patient is examined for cells mediating cell-mediated immunity. What would be the best marker to identify NK cells in the mixture? |
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Definition
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Term
| What is the most important effector mechanism to protect against mycobacteria? |
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Definition
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Term
| A child has suffered multiple infections since about 12 months of age with catalase positive organisms. what is the most likely immunologic defect? |
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Definition
| NAPDH oxidase deficiency (chronic granulomatous disease) |
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Term
| A child with partial oculocutaneous albinism has had recurrent bacterial infections since he was one year old. What is the most likely dx? |
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Definition
| Chediak-Higashi syndrome. Granule structural defect in phagocytic cells and NK cells |
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Term
| 10 year old boy with delayed shedding of primary teeth and facial asymmetry is referred to an immunologist bc of recurrent "cold" staphylococcal abscesses. What is the most likely defect? |
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Definition
| Deficient production of IFN-gamma (Job's syndrome) |
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Term
| A pt has had recurrent sinopulmonary and GI infections since his youth. In which immunoglobulin is he likely to have a selective immunodeficiency? |
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Definition
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Term
| A pt with abnormal susceptibility to extracellular bacteria and opportunist is found to have high serum titers of IgM with no other isotypes present. What is the most likely genetic defect |
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Definition
| Deficiency of CD40L on Tcells |
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Term
| Which disease results form a defect in a tyrosine kinase involved in B lymphocyte maturation? |
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Definition
| Bruton agammaglobulinemia |
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Term
| a teenaged pt suffering from repeated bacterial infections is observed to have normal levels of CD19 positive cells in the peripheral blood, but decreasing levels of immunoglobulin synthesis. what is the most likely diagnosis? |
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Definition
| Common variable hypogammaglobulinemia |
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Term
| A person has suffered repeated meningococcal and gonococcal infections. What is the most likely immunologic defect? |
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Definition
| deficiency of C5,C6,C7,C8 (MAC of complement pathway) |
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Term
| A 5year old child is brought to a pediatrician bc of repeated episodes of swelling of the cutaneous tissues affecting hands, face, larynx and tongue. These attacks are unresponsive to histimines. Serum levels of C2 and C4 are depressed. What is the most lilely defect in the child? |
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Definition
| C1 INH deficiency; hereditary angioedema |
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Term
| A neonate with absence of a thymic shadow radiographically, and hypocalcemic tetany is admitted to the neonatal intensive care unit. What is the most likely dx? |
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Definition
| DiGeorge syndrome; results from the failure of the 3rd and 4th pharyngeal pouches |
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Term
| A patient who is being analyzed for an immunodeficiency disease is found to have depressed IgM levels, thrombocytopenia, and eczema. What is the most likely dx? |
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Definition
| Wiskott-Aldrich syndrome. X-linked defect in a cytoskeletal glycoprotein |
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Term
| A pt who has suffered from repeated viral infections and has failed to make responses to live-attenuated viral vaccines is most likely to have which of the following conditions? |
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Definition
| MHC class I deficiency; results from a failure of TAP 1 molecules to transport peptides to the ER, causing deficiency of CD8+, which are required for protection from viral infections |
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Term
| Flow cytometry of peripheral blood of a pt with SCID reveals normal numbers of CD19 and CD8+ but absence of CD4+ cells. What is the most likely defect? |
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Definition
| MHC class II deficiency (Bare lymphocyte syndrome) |
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Term
| a baby was born with prominent dilatations in the vasculature of the eye and the pinna. What is the most likely dx? |
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Definition
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Term
| What is the receptor that causes HIV to infect macrophages early in infection? |
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Definition
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Term
| How does HIV downregulate MHC class I expression? |
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Definition
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Term
| At what point in the HIV infection does immunologic deviation toward the TH2 cell begin? |
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Definition
| at a CD4 count of 600/mm3 |
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Term
| An HIV positive pt has a CD4:CD8 ratio of 1:2. What is the most likely stage of the infection? |
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Definition
full blown AIDS;
Normal Cd4:CD8 ratio is 2:1 |
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Term
| What is the isotype of the antibody produced against envelope antigens in full blown AIDS? |
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Definition
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