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Immunology Final
Final Info
42
Science
Professional
05/04/2008

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Cards

Term
Hepatities B Vaccine (HBV)
Definition
all newborns receive before leaving hospital, High risk infants (those who's mothers are positive for HBsAg, or who's status is unknown) should receive within 12 hours after birth
Term
Hepatitus A Vaccine
Definition

children at age 1, 2 doses administered 6 months apart

Term
Diptheria and Tetanus Toxoids and Pertussis (Killed) Vaccine combined (DTaP)
Definition

Given to children at 2 months, Diptheria and Tetanus are adjuncts to Pertussis, administered at a young age for protection from Pertussis.

Term
Hemophilus Influenzae Type B Conjugate Vaccines (Hib)
Definition
capsular polysaccharide vaccine. given early because it is largely a pediatric infection
Term
Measles, Mumps, and Rubella Virus Vaccines (Live, attenuated combined) MMR 
Definition

Given after 12 months because live viral vaccines do not work well prior to that do not maternal antibodies .

Disease follow up because there are problems with controlling measles.  

Term
Poliomyelitis Virus Vaccines, Trivalent
Definition

OPV (oral polio vaccine)- "Sabin" no longer used-can actually induce Poliomyelitis

IPV- (inactivated polio Vaccine)-"Salk" eliminates the cases of 4 to 5 OPV induced paralytic polio that occured yearly

Term
Varicella Virus (Live Attenuated)
Definition
prevents chickenpox, 2 doses recommended
Term
Pneumococcal Conjugate Vaccine, 7 Valent (PCV7)
Definition
children age 2-23 months, the seven serotypes are responsible for more than 80% of invasive disease and more than 65% of acute otitis media.
Term
Pneumococcal Conjugate Vaccine 23 Valent (PCV23)
Definition
children greater than or 2 years of age who are high risk, ex: sickle cell anemia, HIV infection, immunocompromising or chronic conditions
Term
Influenza Vaccine
Definition

annual immunization

recommended for children 6-59 months

Live Nasal Vaccine: 2-49 years of age (healthy)

Inactivated Vaccine: children < 2yrs and high risk individuals

Term
Rotovirus Vaccine, Live Oral Tetravalent
Definition

rotavirus leading cause of gastroenteritis, old vaccine removed from market for causing intussusception.

New Vaccine(2007): 1st dose should be administered at 6-12 weeks. Exception to the rule of NOT administering live vaccine to children under 12 months

Term
Meningococcal Conjugate Vaccine
Definition

conjugate polysaccharide

high risk children, adolescents who live in close quarters, can occur in epidemics

Term

Vaccinia Vaccine (Smallpox Vaccine)

Definition

last case of smallpox in 1977. most successful vaccine

Term
Human Papillomavirus Vaccine
Definition
protects against 4 strains of HPV most commonly found in precancerous lesions of the cervix
Term
Omalizumab
Definition

mab, inhibits binding of IgE to mast cells/basophils, reduces Fc receptors on basophils

Term
Abciximab
Definition
mab, anticoagulant, IgG Fab segment specific for glycoproteins IIb/IIIa of platelets
Term
Palivizumab
Definition
mab, anti-infective
Term
Digoxin Immune Fab
Definition

mab, treatment of acute digoxin intoxication

Term
Basiliximab
Definition
immunosuppressive mab, specific for IL2 receptor subunit CD25. prophylaxis of acute renal transplantation rejection
Term
Daclizumab
Definition
immunosuppressive mab, specific for IL2 receptor subunit CD25. prophylaxis of acute renal transplantation rejection
Term
Muromonab CD3
Definition
specific for CD3 on T cells (less specific immunosuppressive mab) prophylaxis of acute renal transplantation rejection
Term
Epoetin Alfa
Definition

cytokine

lot of endocrine bc of its erythropoient qualities, acts largely on bone marrow, indicated for treatment of anemia assoc. with chronic renal failure.

Term
Darbepoetin Alfa
Definition
pegylated version of Epoetin Alfa
Term
Filgrastim
Definition

cytokine

G-CSF drug

major indicationf is for febrile neutropenia of chemotherapy, used to repopulate after bone marrow transplant

Term
Pegfilgrastim
Definition

cytokine

pegylated version of filgrastim

Term
Oprelvekin
Definition

cytokine

IL11, not a true platelet growth factor, but does promote growth of platelets

used to prevent thrombocytopenia of chemotherapy

Term
Sargramostim
Definition

cytokine

GM-CSF

used only for myeloid reconstitution after bone marrow transplant

Term
Type I Alpha Interferons
Definition
used as anti-infectives and antineoplastics
Term
Interferon Alfacon-1
Definition
Chronic HepC
Term
Interferon Alpha-2A
Definition
Leukemias, chronic HepC
Term

Peginterferon Alpha-2A

Definition
Chronic HepC and Chronic HepB
Term

Interferon Alpha-2B

Definition

leukemias, melanoma, chronic HepC, chronic HepB, gential warts

Term
Peginterferon Alpha-2B
Definition
Chronic HepC
Term
Interferon Alpha-2B and Ribovarin
Definition
Chronic HepC
Term
Interferon Alpha-N3
Definition
Gential Warts
Term
Type I Beta Interferons
Definition
management of Multiple Sclerosis
Term
Interferon Beta-1A and Interferon Beta-1B
Definition
Multiple Sclerosis
Term

Type II Interferon

Interferon Gamma-1B

Definition

infections assoc. with chronic granulomatous disease

 activates macrophages

malignant osteopetrosis

Term

Aldesleukin

Definition

recombinant derivative of IL2 and is an IL-1R antagonist. indicated for renal carcinoma and melonoma

many problems with pleiotropy

Term

Becaplermin

Definition

topical cytokine

treatment of diabetic ulcers

platelt derived growth factor

Term
Anakinra
Definition

ANTI-cytokine

IL-1R antagonist  

moderate to severe RA

Term
Etanercept
Definition

TNF-alpha antagonist

RA

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