Term
| Four characteristic of adaptive immunity: |
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Definition
- Antigenic specificity
- Diversity
- Immunologic memory
- Self-nonself recognition |
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Term
| Two branches of adaptive immunity: |
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Definition
Humoral immunity.
Cell-mediated immunity. |
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Term
| Cells involved in humoral immunity: |
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Definition
| B lymphocytes. Antibodies. |
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Term
| Cells involved in cell-mediated immunity: |
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Definition
| T lymphocytes. Antigen presenting cells. |
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Term
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Definition
| The ability of the body to react to a wide variety of foreign antigens, while not reacting to self antigens. |
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Term
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Definition
| The capacity of a substance (immunogen) to induce an immune response. |
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Term
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Definition
| The ability to combine with antibodies or TCR/MHC. |
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Term
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Definition
- A substance that is an antigen but not an immunogen.
-Can be made immunogenic by conjugation to a suitable carrier. |
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Term
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Definition
| Substance mixed with antigen to enhance immunogenicity. |
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Term
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Definition
| The portion of an antigen (small molecular group) which is recognized by Ab or TCR/MHC. |
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Term
| What cells/molecules are most antigenic? |
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Definition
| Foreign cells and large complex molecules over 10,000 MW. |
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Term
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Definition
| Free antigen; epitopes accessible on surface. |
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Term
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Definition
| Processed (internal) antigen; epitopes from linear peptides. |
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Term
| Where on the antibody are disulfide bonds located? |
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Definition
| Between/connecting heavy chains, and connecting heavy chain to light chain. |
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Term
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Definition
| Antigen Binding Fragment - top Y portion of the antibody. |
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Term
| Where do T lymphocytes originate? Mature? |
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Definition
Originate in the bone marrow.
Mature in the thymus. |
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Term
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Definition
| Membrane bound receptor that recognizes antigen only when combined with MHC molecules. |
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Term
Where are MHC class I found?
What do they interact with? |
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Definition
- Present on most nucleated cells.
- Interacts with CD8+ cells, T cytotoxic cell (TC) |
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Term
Where are MHC class II found?
What do they interact with? |
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Definition
- Only antigen-presenting cells.
- Interacts with CD4+ cells, T helper cell (TH) |
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Term
| Primary receptors found on Th1 and Th2: |
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Definition
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Term
| Functions and features of Th1: |
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Definition
- Activates other CD4 and CD8 cells.
- Secretes IL-2, tumor necrosis factor (TNF), and interferon-gamma (IFN-gamma)
- Responsible for delayed hypersensitivity.
- Interacts with MHC II receptors. |
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Term
| Functions and features of Th2: |
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Definition
- Drives B cell proliferation.
- Secretes IL-4, IL-5, IL-6 and IL-10.
- Can dampen Th1 activity. |
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Term
| Primary receptor on Tc cell: |
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Definition
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Term
| Functions and features of Tc cells: |
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Definition
- Destroys targeted foreign cells by lysis.
- Important in the destruction of complex microbes, cancer cells, and virus-infected cells.
- Part of graft rejection.
- Requires MHC I for function. |
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