Term
|
Definition
| phagocytic and important in bacterial defense |
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Term
|
Definition
| determines the type, direction and magnitude of the immune response via cytokine secretion |
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Term
|
Definition
| has a receptor for IgG, induces apoptosis in target cell, and is important in tumor immunity |
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Term
|
Definition
| permits expression of only one "form" of immunoglobulin on the surface of the B lymphocyte |
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Term
|
Definition
| point mutation that occurs in the variable region of gene segments of immunoglobulin genes after B cell activation |
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Term
|
Definition
| degranulated in the C3a, C4a, and C5a pathway |
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Term
|
Definition
| important function of the complement component C3b (by itself, not in the pathway) |
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Term
|
Definition
| not a component of the innate immune system |
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Term
|
Definition
| levels increased in the presence of a parasite |
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Term
|
Definition
| lymphocyte most responsible for allergy to food proteins |
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Term
|
Definition
| do not express antigen receptors |
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Term
|
Definition
| is a primary lymphoid organ |
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|
Term
| Bacterial Surface Proteins |
|
Definition
| are the most potent immunogen |
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Term
|
Definition
| levels will be highest (higher than other Ig's) early on in infection AKA is the first Ig "on the scene" |
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Term
|
Definition
| can lead to offspring with apparent immunodeficiency |
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Term
|
Definition
| is expressed on T helper cells |
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Term
|
Definition
| is expressed on cytotoxic T cells |
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Term
|
Definition
| are an example of pattern recognition receptors |
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Term
|
Definition
| are used by phagocytes to recognize infectious agents |
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|
Term
| Parvovirus Capsid Proteins |
|
Definition
| may be recognized by T cells |
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Term
|
Definition
| region of Ig that determines antigenic specificity |
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Term
|
Definition
| region of Ig that determines the class of Ig |
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Term
|
Definition
| deficiency of this immunoglobulin may lead to immunodeficiency against respiratory infections |
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Term
|
Definition
| immunoglobulins able to activate the complement cascade |
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Term
|
Definition
| what happens to lymphocytes with nonproductive rearrangement of their antigen receptor genes |
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Term
|
Definition
| activates the classical complement pathway |
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Term
|
Definition
| activates the alternative complement pathway |
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Term
|
Definition
| mechanisms for the complement pathway (in addition to classical & alternative) |
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|
Term
| Heavy Chain Constant Region |
|
Definition
| where an antibody that binds specifically to IgE will bind |
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Term
|
Definition
| binds IgE and mediates allergic reactions as well as parasitic defense |
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Term
|
Definition
| expression changed during class switching |
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|
Term
|
Definition
| altered during class switching |
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|
Term
|
Definition
| affected by somatic mutation of immunoglobulins |
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Term
|
Definition
| found in liver; example of fixed tissue dendritic cell |
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|
Term
|
Definition
| found in the skin; example of fixed tissue dendritic cell |
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|
Term
|
Definition
| important for removal of immune complexes by the spleen |
|
|
Term
| DNA Arrangement & Splicing |
|
Definition
| creates antigenic diversity of immunoglobulins |
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|
Term
|
Definition
| undergo a process during maturation that insures the resultant cell is tolerant to self |
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|
Term
|
Definition
| antigen recognition of this cell may be altered by abnormal expression of MHC I and MHC II |
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Term
|
Definition
| more prominent in animals whose spleen has been removed |
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|
Term
|
Definition
| used in dendritic cells to recognize pathogens for phagocytosis |
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|
Term
|
Definition
| one of the most important antigen presenting cells |
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|
Term
|
Definition
|
|
Term
|
Definition
| do not have antigen receptors |
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|
Term
|
Definition
| important for defense against parasites |
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|
Term
|
Definition
| means facilitation of phagocytosis |
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|
Term
|
Definition
| express high concentrations of MHC II |
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|
Term
|
Definition
|
|
Term
|
Definition
| recognize difference biochemical antigenic structures |
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|
Term
|
Definition
| specialize cells that overlay Peyer's patches |
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|
Term
|
Definition
| are present in the intestines |
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|
Term
|
Definition
|
|
Term
|
Definition
| important activity in amplificaiton of the complement pathway |
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|
Term
|
Definition
|
|
Term
|
Definition
| important in removal of immune complexes by the spleen |
|
|
Term
| Heavy Chain Constant Region |
|
Definition
| determines the class or isotype of immunoglobulin |
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|
Term
|
Definition
| does not generate diveresity in the antigen recognition site of antibodies |
|
|
Term
|
Definition
| fate of B lymphocytes that do not successfully rearrange their Ig genes |
|
|
Term
| Affinity Maturation of B Lymphocytes |
|
Definition
| occurs after antigen recognition and activation |
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|
Term
|
Definition
| have the ability to recognize foreign substances because they express toll-like receptors |
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|
Term
|
Definition
| may lead to recurrent episodes of respiratory tract infections |
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|
Term
|
Definition
| impairs antigen processing for MHC I expression |
|
|
Term
| Heavy Chain Constant Region |
|
Definition
| antibody that specifically binds to IgM binds to this region |
|
|
Term
| Recent Canine Parvovirus Infection |
|
Definition
| causes detection of CPV-specific IgM in a dog |
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|
Term
|
Definition
| site of B lymphocyte activation and IgA production in a calf with rotavirus, which causes diarrhea |
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|
Term
|
Definition
| best Ig for agglutination |
|
|
Term
|
Definition
|
|
Term
|
Definition
| involved in allergic reactions |
|
|
Term
|
Definition
| one molecule of this Ig can activate complement |
|
|
Term
|
Definition
| major Ig produced in immune response |
|
|
Term
|
Definition
| are secreted by plasma cells |
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|
Term
|
Definition
| "first responder" immunoglobulin |
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|
Term
|
Definition
| expressed on surface of naive B cells |
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|
Term
|
Definition
| recognize conformation-dependent epitopes |
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|
Term
|
Definition
| anatomic barrier to pathogens |
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|
Term
|
Definition
|
|
Term
|
Definition
| antigen-binding region of immunoglobulin |
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|
Term
|
Definition
|
|
Term
|
Definition
| important in parasitic infection and allergies |
|
|
Term
| Iga/IgB (a, alpha; B, beta) |
|
Definition
| functions in B lymphocyte signal transduction |
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|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| functions in cytosolic antigen processing pathway |
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|
Term
|
Definition
| opsonizing complement component |
|
|
Term
|
Definition
| three mechanisms: classical, alternative, lectin |
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|
Term
|
Definition
| characterized by four signs: calor, dolor, tumor, rubor |
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|
Term
|
Definition
| distinguished by: memory, specificity, diversity, and self/nonself recognition |
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|
Term
|
Definition
| ability determined by: susceptibility to processing, complexity/chemical composition, size, foreignness |
|
|
Term
|
Definition
| part of antigen that binds with its receptor |
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|
Term
|
Definition
| only recognize soluble epitopes |
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|
Term
|
Definition
| only recognize processed antigens |
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