Term
| How to interpret a blood typing immunoassay |
|
Definition
| if it agglutinates in the anti serum it is that blood type. |
|
|
Term
| detection immunoassay is tagged with an enzyme that cleaves a colorless substrate to yield a colored product. Colored product= positive reaction |
|
Definition
|
|
Term
| example of an enzyme immunoassay test |
|
Definition
home pregnancy test
initial screen for HIV |
|
|
Term
| which immunoassay uses a sandwhich configuration |
|
Definition
|
|
Term
| HIV western blot antigens |
|
Definition
|
|
Term
| How long is the incubation period for HIV |
|
Definition
|
|
Term
| What test is often used for HIV |
|
Definition
|
|
Term
| results for HIV western blot |
|
Definition
positive= 2 antigens
indeterminate= 1 antigen
negative= no antigens |
|
|
Term
| If HIV EIA is positive.... |
|
Definition
retest to confirm.
If negative- patient clean
If postiive- confirm with western blot of IFA |
|
|
Term
| what are the best specimens for HIV western blot |
|
Definition
| plasma, whole blood, serum |
|
|
Term
| immunoassay for congenital infections |
|
Definition
| ELISA-enayme linked immunoabsorbent assay |
|
|
Term
| this immuno assay is done with a solid phase on a microtiter plate so that color formation is in fluid. read with a spectrophotometer. |
|
Definition
|
|
Term
| darkest color has more antibodies, higher spectrophotometer |
|
Definition
|
|
Term
|
Definition
| inverse of most dilute concentration that yields a positive result. |
|
|
Term
high WBC
indicates infection, inflammation, tissue trauma
leukemia |
|
Definition
|
|
Term
low WBC
bone marrow failure |
|
Definition
|
|
Term
Leukocytosis of Tcell, Bcell, NKs
indicates acute viral infection |
|
Definition
|
|
Term
leukocytosis of PMN
indicaties acute bacterial infections
left shift due to increased bands/stabs |
|
Definition
|
|
Term
| leukopenia for neutrophils which comprise most of your WBC |
|
Definition
|
|
Term
|
Definition
|
|
Term
| disrupts C1qrs complex at beginning of Classic complement pathway. |
|
Definition
|
|
Term
|
Definition
|
|
Term
| Disrupts C3bBb before it becomes C3 convertase in alternate complement pathway |
|
Definition
|
|
Term
deficiency in C1INH
disrupts C1qrs complex at beginning of Classic complement pathway.
Disrupts MASP
Disrupts C3bBb before it becomes C3 convertase in alternate complement pathway |
|
Definition
blocks the complement pathway
which lysis the gram negative bacteria |
|
|
Term
| RBC lysed for dark urine in the morning |
|
Definition
| Paroxysmal Nocturnal Hemoglobinuria |
|
|
Term
DAF- defective GPI anchors
blocks C4 from phosphorylating so no complement pathway |
|
Definition
| Paroxysmal Nocturnal Hemoglobinuria |
|
|
Term
weakness
headaches
eye pain
splenomegaly
thrombocytopenia |
|
Definition
| Paroxysmal Nocturnal Hemoglobinuria |
|
|
Term
pateint susceptible to encapsulated bacteria
often streptococcus pneumonia
Flu
Neisseria |
|
Definition
|
|
Term
| cannot produce MAC which lyses Gram negative bacteria |
|
Definition
|
|
Term
susceptible to infections
common in babies with no passive immunity |
|
Definition
MBL deficiency
MBL is similar to C1q |
|
|
Term
caused by AIRE defect
AIRE- autoimmune regulatory effect |
|
Definition
| AI polyendrocrine syndrome |
|
|
Term
| recognizes self, and keeps you from killing own cells |
|
Definition
|
|
Term
| destroys self cells (autoreactive T cells cant be deleted) |
|
Definition
| AI polyendrocrine syndrome |
|
|
Term
| symptoms; hypoparathyroidism, adrenal insufficiency, thyroiditis, type ! diabetes, ovarian failure |
|
Definition
| AI polyendrocrine syndrome |
|
|
Term
| Defective phagocyte NADPH oxidase |
|
Definition
| chronic granulomatous disease |
|
|
Term
presents by age 2
repeated bacterial/fungal infection |
|
Definition
| chronic granulomatous disease |
|
|
Term
| part of the respiratory burst, breaks down particles once they are phagocytized |
|
Definition
|
|
Term
symptoms
granulomas, lymph node infection. abcesses in skin, liver, viscera |
|
Definition
| chronic granulomatous disease |
|
|
Term
Chromosome 22q11.2 deletion
undeveloped throid paracortex |
|
Definition
|
|
Term
| highly susceptible to viral infections due to few no T cells |
|
Definition
|
|
Term
B cells cannot class switch to other antibody types.
TH2 CD40 ligand defect |
|
Definition
|
|
Term
| defends skin and mucous membranes immunoglobulin |
|
Definition
|
|
Term
| blood products can cause anaphylaxis because of this immunoglobulin |
|
Definition
|
|
Term
| lack of immuno causes susceptibility to infections |
|
Definition
|
|
Term
| K light chain gene expression problem |
|
Definition
| Severe Combined Immunodeficiency (SCID) |
|
|
Term
| Deficiency in RAG 1 and 2 proteinds |
|
Definition
|
|
Term
| cannot make functions Antibodies or TCR molecules |
|
Definition
|
|
Term
|
Definition
Rh- mother with Rh+ fetus during first baby is OK
2nd time, Rh+ fetus is attacks by anti-RH antibodies produced in mom during first pregnancy. |
|
|
Term
| test evaluates BABYs RBCs for bound mother's anti RH IgG |
|
Definition
|
|
Term
| tests mothers serum for circulating anti RH IgG |
|
Definition
|
|
Term
No CD18
prevents all cells leaving blood stream to the tissue |
|
Definition
| Luekocyte Adhesion Deficiency |
|
|
Term
|
Definition
|
|
Term
leukocytosis, especially neutrophila
leads to chronic bacterial infections in the mouth and GIT |
|
Definition
| Leukocyte Adhesion Deficiency |
|
|
Term
| No pus and impaired wound healing |
|
Definition
| Leukocyte Adhesion Deficiency |
|
|
Term
|
Definition
| Leukocytes Adhesion Deficiency |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| what helps with recovery of bone marrow |
|
Definition
| Filgrastim an Sargramostim |
|
|
Term
|
Definition
|
|
Term
| what can reverse thrombocytopenia |
|
Definition
Oprelvekin
Thrombopoietn (TPO) |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| proliferation/ activation of Tc and NK |
|
|
Term
|
Definition
|
|
Term
|
Definition
| attacks tumors, activates PMN, and promotes wound healing |
|
|
Term
| what T cell helps with CMI |
|
Definition
|
|
Term
| what T cell helps with helminthes/allergens |
|
Definition
|
|
Term
|
Definition
|
|
Term
| promotes class switch to IgE |
|
Definition
|
|
Term
|
Definition
|
|
Term
class switch to IgA
eosinophil activation |
|
Definition
|
|
Term
| what T cell helps with fungi and bacteria |
|
Definition
|
|
Term
|
Definition
|
|
Term
| stimulates antimicrobial production by neutrophil and epithelium |
|
Definition
|
|
Term
works with what T cell
CD3 CD4 CD25 |
|
Definition
|
|
Term
works with what T cell
CD3 and CD8 |
|
Definition
|
|
Term
works with what Tcell
CD3 and CD4 |
|
Definition
|
|
Term
| what does Rag1 and Rag 2 do... |
|
Definition
| they allow VDJ recombination, so no antibodies produced |
|
|
Term
| what MHC does CD4 and Treg |
|
Definition
|
|
Term
| prevents Autoimmune reactions (tcell) |
|
Definition
|
|
Term
|
Definition
|
|
Term
| inhibits TH1 and macrophages |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| cytoxic killers of infected hosts |
|
Definition
|
|
Term
| half life of 23 days (longest) |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| ADCC (antidependent cell mediated cytotoxicity) with CD16 bearing NK cells |
|
Definition
|
|
Term
|
Definition
|
|
Term
| major isotype in secondary immune |
|
Definition
|
|
Term
| can be elevated due to previous vaccination or infection |
|
Definition
|
|
Term
| primary Antibody responder |
|
Definition
|
|
Term
|
Definition
|
|
Term
| best agglutinator - valence 10 |
|
Definition
|
|
Term
| elevate levels indicate acute infection |
|
Definition
|
|
Term
| only antibodies made by the fetus |
|
Definition
|
|
Term
| causes agglutination in ABO blood typing |
|
Definition
|
|
Term
|
Definition
|
|
Term
| found in seromucous secretions |
|
Definition
|
|
Term
| protects GI/respiratory tract |
|
Definition
|
|
Term
|
Definition
|
|
Term
| secretory component protects from proteases |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| light chain Episilon receptor |
|
Definition
|
|
Term
| causes degranulation of basophils, mast cells, eosinophils |
|
Definition
|
|
Term
| effective against worms and allergens (hypersensitivity) |
|
Definition
|
|
Term
|
Definition
|
|
Term
| coexpressed with IgM on mature but naive B cells |
|
Definition
|
|
Term
| B cell differentiate into plasma cell that secretes mostly IgM and low amounts of .... |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| major site of hematopoiesis |
|
Definition
| Bone marrow in sternum vertebrae, iliac bones and ribs |
|
|
Term
|
Definition
| helps stem cells get ready for transplantation |
|
|
Term
| differentiation of stem cells by CSF and IL made by macrophages/stromal cells |
|
Definition
|
|
Term
|
Definition
|
|
Term
| part of the Thymus with percursor T cells |
|
Definition
|
|
Term
| part of the Thymus with mature T cells |
|
Definition
|
|
Term
| site of negative selection of autoreactive t cells |
|
Definition
|
|
Term
| present const. expressed antigens to T cells |
|
Definition
|
|
Term
| present nonthymic antigens |
|
Definition
|
|
Term
|
Definition
| dendritic cells that precent to Tc cells |
|
|
Term
|
Definition
|
|
Term
| handles blood borne antigens |
|
Definition
|
|
Term
| major site for antibody synthesis |
|
Definition
|
|
Term
| asplenic patients are susceptible ,,, |
|
Definition
|
|
Term
| red pulps recycles iron in the... |
|
Definition
|
|
Term
| PALS- periarterial lymphatic system in....pulp |
|
Definition
|
|
Term
| store and activate B and T cells |
|
Definition
|
|
Term
|
Definition
|
|
Term
| part of the Lymph nodes with Bcells |
|
Definition
|
|
Term
| part of the lymph nodes with T cells |
|
Definition
|
|
Term
|
Definition
| mucosa associated lymphoid tissue |
|
|
Term
|
Definition
|
|
Term
| mucous layers in the intestine that allow antigens into the tissue to be shown to the tcells |
|
Definition
|
|
Term
|
Definition
| tonsils, adenoids, appendix, lamina propria |
|
|
Term
| CD marker for the B lymphocytes |
|
Definition
CD19 CD20 CD21
antibody secretion |
|
|
Term
| CD marker for all T lymphcytes |
|
Definition
|
|
Term
|
Definition
CD3 and CD4
cytokine secretion |
|
|
Term
|
Definition
CD 3 CD4 CD25
prevent autoimmunity |
|
|
Term
|
Definition
CD3 Cd8
kills infected cells/tumors/grafts |
|
|
Term
|
Definition
CD 16 CD56
kills infected cells tumors grafts |
|
|
Term
| differentiates lymphoid lineage |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| HLA is encoded on what chromosome |
|
Definition
|
|
Term
|
Definition
| combination of class 1 and 2 MHCs |
|
|
Term
| percentage of haplotype from parents |
|
Definition
|
|
Term
| percentage of haplotype similar to siblings |
|
Definition
|
|
Term
what cells do this...
cytokine secretion
elimination of intracellular pathogens
prevention of AI |
|
Definition
|
|
Term
cells that do this...
eliminate infected host cells
help with ADCC |
|
Definition
|
|
Term
cells that can...
long lived phagocytes and are APC |
|
Definition
| monocytes and macrophages |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| type of cells do this...phagocytosis, promote inflammation, short lived but fast responders |
|
Definition
|
|
Term
|
Definition
|
|
Term
| High affinity Fc receptors of IgE in what cells |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| Epstein Barr interferes with ... |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| pathogen associated molecular patterns |
|
|
Term
|
Definition
| pattern recognition receptors |
|
|
Term
|
Definition
|
|
Term
| potent endogenous pyrogen... |
|
Definition
|
|
Term
|
Definition
|
|
