Term
| HLA A3 is associated with.. |
|
Definition
|
|
Term
| HLA B27 is associated with... |
|
Definition
| psoriatic arthritis, ankylosing spondylitis, IBD, reiter's syndrome |
|
|
Term
| HLA B8 is associated with... |
|
Definition
|
|
Term
| HLA DR2 is associated with... |
|
Definition
| multiple sclerosis, hay fever, SLE, goodpastures |
|
|
Term
| HLA DR 3 is associated with... |
|
Definition
|
|
Term
| HLA DR4 is associated with... |
|
Definition
| rheumatoid arthritis and DM type 1 |
|
|
Term
| HLA DR5 is associated with... |
|
Definition
| pernicious anemia leading to B12 def; hashimoto's thyroiditis |
|
|
Term
| HLA DR7 is associated with... |
|
Definition
| steroid responsive nephrotic syndrome |
|
|
Term
| What cytokines enhance the ability of natural killer cells? |
|
Definition
| IL-12, IFN beta and IFN alpha |
|
|
Term
| What is the costimulatory signal for CD4 cells? |
|
Definition
| B 7 on antigen presenting cell binds with CD 28 on CD4 cell |
|
|
Term
| What is signal 2 for activating cytotoxic T cells? |
|
Definition
| IL2 from Th cell activates Tc cell to kill virus infected cell |
|
|
Term
| What are the necessary signals for B cell activation and class switching? |
|
Definition
| B cell presents antigen on MHC II and it is recognized by TCR of TH2 cell; TH2 cell then releases IL-4, 5, and 6= signal one; then CD40 receptor on B cell binds CD 40L on Th cell= signal two; costimulatory signal= interaction between B7 on B cell and CD 28 on T cell |
|
|
Term
| What CD markers are expressed by Tregs? |
|
Definition
|
|
Term
| What cytokines are produced by Treg cells? |
|
Definition
|
|
Term
| Name the receptors found on macrophages? |
|
Definition
| CD 14, CD 40, MHC II, B7, Fc and C3b receptors to enhance phagocytosis |
|
|
Term
| How does endotoxin/lipopolysaccharide stimulate the immune system? |
|
Definition
| binds to macrophages CD14 receptor (Th cells are not involved) |
|
|
Term
| What bacteria has two flagellar variants? |
|
Definition
|
|
Term
| What parasite exhibits programmed antigen variation? |
|
Definition
|
|
Term
| What type of hypersensitivity is rheumatic fever? |
|
Definition
|
|
Term
| What type of hypersensitivity is pernicious anemia? |
|
Definition
|
|
Term
| What type of hypersensitivity causes the symptoms of SLE? |
|
Definition
|
|
Term
| What type of hypersensitivity causes rheumatoid arthritis? |
|
Definition
|
|
Term
| What type of hypersensitivity is associated with polyarteritis nodosum? |
|
Definition
|
|
Term
| What type of hypersensitivity is associated with hypersensitivity pneumonitis? |
|
Definition
|
|
Term
| What type of hypersensitivity is Hashimoto's? |
|
Definition
|
|
Term
| MS and guillan barre are both examples of what type of hypersenstivity? |
|
Definition
|
|
Term
| DM I is what type of hypersensitivity? |
|
Definition
|
|
Term
| What type of hypersenstivity is febrile, nonhemolytic transfusion reaction? |
|
Definition
|
|
Term
| What is the antibody associated with scleroderma (diffuse)? |
|
Definition
| anti-Scl-70 (anti DNA topoisomerase I) |
|
|
Term
| What disease is associated with anti-desmoglein? |
|
Definition
|
|
Term
| What is the antibody associated with polymyositis or dermatomyositis? |
|
Definition
|
|
Term
| What are the antibodies associated with Sjogren's syndrome? |
|
Definition
| anti SS-A (ro), anti SS-B (la) |
|
|
Term
| What is anti-U1 RNP found in? |
|
Definition
| mixed connective tissue disease |
|
|
Term
| What is the antibody found in type I DM? |
|
Definition
| anti-glutamate decarboxylase |
|
|
Term
| Having a deficiency in granulocytes will predispose you to what bacteria? |
|
Definition
|
|
Term
| What is the defect in hyper-IgM syndrome? |
|
Definition
| no CD 40L on T cells so B cells can't class switch |
|
|
Term
| What are the effects of a defect in IL-12 receptor? |
|
Definition
| decreased TH1 response so you see decreased IFN gamma on labs; leads to mycobacterial infections |
|
|
Term
| Chronic infections by candida albicans with no other problems is indicative of what immunodeficiency? |
|
Definition
| chronic mucocutaneous candidiasis (d/t a t cell dysfunction) |
|
|
