Term
| 3 serum findings post-splenectomy |
|
Definition
Howell-Jolly bodies (nuclear remnants)
Target cells
Thrombocytosis |
|
|
Term
| What is the general function of Interferons (α,β,γ)? |
|
Definition
| They place uninfected cells in an antiviral state and activate NK cells to kill virus infected cells. |
|
|
Term
| What is the function of α and β interferons? |
|
Definition
| They produce a ribonuclease that inhibits viral protein synthesis by degrading viral mRNA (but not host mRNA). |
|
|
Term
| What is the antiviral function of interferon-γ? |
|
Definition
| It increases MHC I and II expression and antigen presentation in all cells. |
|
|
Term
Name 3 cell surface proteins/markers on T cells and what is their function?
(not including CD4 and CD8) |
|
Definition
TCR (binds antigen-MHC complex)
CD3 (associated with TCR for signal transduction)
CD28 (binds B7 on APC) |
|
|
Term
| Name 7 cell surface proteins/markers on B cells. |
|
Definition
Ig
CD19, CD20, CD21, CD40
MHC II, B7 |
|
|
Term
| Name 4 cell surface proteins/markers on Macrophages |
|
Definition
|
|
Term
| Name 2 cell surface proteins/markers on NK cells and describe their function. |
|
Definition
CD16 (binds Fc of IgG)
CD56 |
|
|
Term
| How do superantigens work? |
|
Definition
| They cross-link T-cell receptors to MHC II on APCs to cause uncoordinated release of IFN-γ from Th1 cells |
|
|
Term
| What antigen can directly stimulate macrophages and how? |
|
Definition
Endotoxins/LPS (gram - bacteria)
they bind to endotoxin receptor CD14 on macrophages |
|
|
Term
| 4 common live attenuated vaccines |
|
Definition
Measles
Mumps
Rubella
Varicella |
|
|
Term
| 4 common inactivated or killed vaccines |
|
Definition
Cholera
Influenza
Hep A
Rabies |
|
|
Term
| Which hypersensitivity reactions are antibody mediated? |
|
Definition
Types I, II, and III
(IV is T cell mediated) |
|
|
Term
| Give a brief description of each hypersensitivity reaction I-IV. |
|
Definition
I. Anaphylactic and Atopic (IgE mediated)
II. Cytotoxic (IgG or IgM mediated)
III. Immune complexes
IV. Delayed (T cell mediated) |
|
|
Term
| 2 tests for Type I hypersensitivity reactions. |
|
Definition
Scratch test
Radioimmunosorbent assay |
|
|
Term
| 2 tests for Type II hypersensitivity reactions. |
|
Definition
| Direct and indirect Coombs' |
|
|
Term
| 1 tests for Type III hypersensitivity reactions. |
|
Definition
| Immunofluorescent staining |
|
|
Term
| 1 tests for Type IV hypersensitivity reactions. |
|
Definition
|
|
Term
|
Definition
| Type III hypersensitivity reaction where there's edema, necrosis, and activation of complement where an intradermal injection occurred. |
|
|
Term
| Hemolytic anemia is a Type ___ hypersensitivity reaction. |
|
Definition
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