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Immunology 3
Immunology First Aid 2012
23
Medical
Professional
05/28/2013

Additional Medical Flashcards

 


 

Cards

Term
Which Ig crosses the placenta?
Definition
IgG
Term
Which Ig neutralizes bacterial toxins and viruses?
Definition
IgG
Term
What is the size of IgA?
Definition
Monomer in circulation, dimer when secreted
Term
How does the size of IgA change?
Definition
It picks up it's secretory component from epithelial cells before secretion
Term
Which Ig is an antigen receptor on the surface of B cells?
Definition
IgM
Term
What does IgE do?
Definition

Binds mast cells and basophils and crosslinks when exposed to allergen

 

also activates eosinophils against worms

Term
Which Ig is normally in lowest concentration serum?
Definition
IgE
Term
C1 esterase inhibitor deficiency (complement deficiency) causes what problem(s)?
Definition

Hereditary angioedema

 

ACE inhibitors are contraindicated in this disease

Term
C3 deficiency (complement deficiency) causes what problem(s)?
Definition
Severe, recurrent pyogenic sinus and respiratory tract infections, also increased suceptibility to type III hypersensitivity reactions
Term
C5-C9 deficiency (complement deficiency) causes what problem(s)?
Definition
recurrent Neisseria bacteremia
Term
DAF (GPI anchored enzyme) deficiency causes what problem(s)?
Definition
complement-mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria (PNH)
Term
What cell secretes IL-1 and what is the action of this cytokine?
Definition

Macrophage

 

Endogenous pyogen- causes fever, acute inflammation. Activates endothelium to express adhesion molecules; induces chemokine secretion to recruit leukocytes

Term
What cell secretes IL-6 and what is the action of this cytokine?
Definition

Macrophages or Th2 cells

 

Endogenous pyogen. Causes fever and stimulates production of acute-phase-proteins.

Term
What cell secretes IL-8 and what is the action of this cytokine?
Definition

Macrophage

 

Major chemotactic factor for neutrophils.

Term
What cell secretes IL-12 and what is the action of this cytokine?
Definition

Macrophage and B cells

 

Induces differentiation of T cells into Th1 cells. Activates NK cells.

Term
What cell secretes TNFα and what is the action of this cytokine?
Definition

Macrophage

 

Mediates septic shock. Activates endothelium. Causes leukocyte recruitment, vascular leak.

Term
What cell secretes IL-3 and what is the action of this cytokine?
Definition

All T cells

 

Supports growth and differentiation of bone marrow stem cells.

Term
What cell secretes IL-2 and what is the action of this cytokine?
Definition

Th1 cell

 

Stimulates growth of helper and cytotoxic T cells.

Term
What cell secretes Interferon-γ and what is the action of this cytokine?
Definition

Th1 cell

 

Activates macrophages and Th1 cells. Suppresses Th2 cells. Has antiviral and antitumor properties.

Term
What cell secretes IL-4 and what is the action of this cytokine?
Definition

Th2 cells

 

Induces differentiation into Th2 cells. Promotes growth of B cells. Enhances class switching to IgE and IgG.

Term
What cell secretes IL-5 and what is the action of this cytokine?
Definition

Th2 cells

 

Promotes differentiation of B cells. Enhances class switching to IgA. Stimulates growth and differentiation of eosinophils.

Term
What cell secretes IL-10 and what is the action of this cytokine?
Definition

Th2 cells and regulatory T cells

 

Modulates inflammatory response. Inhibits actions of activated T cells and Th1. Activates Th2.

Term
2 cytokines that are anti-inflammatory
Definition
IL-10 and TGF-β
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