Term
cell mediating immune response:
neutrophils
produced in....
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Definition
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Term
cell mediating immune response:
basophils, eosinophils, monocytes, lymphocytes
produced in.... |
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Definition
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Term
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Definition
| B cells, plasma cells, T cells, and third population cells |
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Term
cell mediating immune response:
lymphoctyes
produced in.... |
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Definition
| bone marrow, thymus, and peripheral lymphoid organs |
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Term
| T cells, which include CD8 cytotoxic T cells and CD4 helper cells include: |
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Definition
| Th1 (Type 1) and Th2 (Type 2) cells |
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Term
| Third population cells include: |
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Definition
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Term
| Dendritic cells are produced in: |
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Definition
| tissues and lymphoid organs |
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Term
| Macrophages are produced in: |
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Definition
| almost all tissues and organs and differentiate from blood-borne monocytes |
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Term
| Mast cells are produced in: |
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Definition
| almost all tissues and organs and differentiate from basophils |
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Term
Natural or Innate Immune Response (INFLAMMATION)
5 attributes |
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Definition
1. immune defenses to infection or injury that lacks memory
2. elicited by a variety of injurious agents
3. stereotypic response
4. Purpose: destroy invaders or set stage for repair
5. Key actors: phagoctyic cells, cells that release inflammatory mediators, and natural killer cells
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Term
| Sequence of EVENTS of typical inflammatory response: |
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Definition
1. intial entry
2. vasodilation
3. marked protein permeability
4. exit of neutrophils, monoctyes
5. phagocytosis
6. tissue repair |
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Term
| Plasma proteins are a source for: |
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Definition
| acute phase proteins, complement, products of blood clotting |
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Term
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Definition
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Term
| Monoctyes and macrophages are responsible for the release of: |
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Definition
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Term
| lysosomal enzymes and O2 derived substances originate from: |
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Definition
| neutrophils and macrophages |
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Term
| Lymphocytes are a source for: |
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Definition
| antibodies and lymphokines |
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Term
| Clonal selection leading to B and T lymphocyte action during primary immune reponses generates efector T and B cells/ memory T and B cells is: |
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Definition
| part of an acquired immune response |
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Term
| Two broad categories of acquired immune responses: |
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Definition
| antibody-mediated or cell-mediated |
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Term
| Three stages of an immune response: |
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Definition
1. antigen encounter
2. lymphocyte activation
3. attack |
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Term
| Antibody-mediated/humoral responses: |
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Definition
| involves B cells, mediated by antibodies, secreted by plasma cells, arise from B cells, major protection against bacteria or viruses in extracellular fluid |
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Term
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Definition
| involves CD8 T cells or cytotoxic killer cells, a major defense against intracellular viruses |
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Term
Corticosteroids
MoA, Effects |
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Definition
Corticosteroids
MoA: bind to glucocorticoid receptors
Effects: increases PMN concentration, lymphocyte concentration, monocytes, etc.
maximal change a 6 hours. Reduces antigens, mitogens, and cytokines and enzymes
inhibit PLA, lower PG/LKEm induce secretion lipocortinsm ibhibit COX2, vasoconstrictive, inhibit complement, reduce AB production |
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Term
Corticosteroids
KE, ADRs, Uses |
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Definition
Corticosteroids
KE: oral use, metabolized in liver, excreted by kidneys
ADRs: toxic in short periods, longer periods lead to iatrogenic Cushing's syndrome
GI peptic ulcers, bacterial/mycotic infections, adrenal suppression, obesity, dyslipidemia, glucose intolerance
Uses: see lectures |
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Term
Cytotxoic and Antiproliferative Agents:
Cyclophosamide
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Definition
Cyclophosamide
MoA: alykylating agent, SIGNAL 3 inhibitor, non cell cycle specific, inhibits B and T cells
ADRs: NV, bone marrow suppression ,aspermia
Uses: RA, leukemias and other tumors
PK: Oral, IV |
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Term
Cytotxoic and Antiproliferative Agents:
Azathiorpine
Structure:
MoA:
Use:
Toxicity:
Other: |
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Definition
Azathiorpine
Structure: purine analog
MoA: antimetabolite, SIGNAL 3, cell cycle specific, T > > B
Use: renal allotransplantation, RA
Toxicity: NV, bone marrow supression, infection
Other: Oral, IV
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Term
Cytotxoic and Antiproliferative Agents:
MTX (methotrexate)
Structure:
MoA:
Use:
Toxicity:
Other: |
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Definition
Cytotxoic and Antiproliferative Agents:
MTX
Structure: folic acid analog
MoA: antimetabolite, SIGNAL 3, CELL CYCLE specific, inhibit B and T
Use: Crohn's Disease, RA, Leukemias, Other Tumors
Toxicity: NV, bone marrow suppression, hepatotoxicity
Other: ORAL, IV |
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Term
Cytotxoic and Antiproliferative Agents:
Mycophenolate Mofetil
Structure:
MoA:
Use:
Toxicity:
Other: |
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Definition
Cytotxoic and Antiproliferative Agents:
Mycophenolate Mofetil
Structure:
MoA:
Use:
Toxicity:
Other: |
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