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Immunologic Tolerance and Autoimmunity
Test 1 Sem. 2
10
Medical
Graduate
01/10/2011

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Cards

Term
What are the 3 mechanisms of tolerance?
Definition
Clonal depletion, clonal anergy and t-cell mediated suppression.
Term
What is the most potent costimulatory molecules for peripheral tolerance are?
Definition
CD28 and CD154
Term
WHat is the classic example of autoimmunity?
Definition
Rheumatic heart disease from streptococcal antibodies.
Term
Antibodies to borrelia/Lyme dz attack what target tissue?
Definition
Synovium, causing Lyme arthritis
Term
What do most pts with Myasthenia gravis have?
Definition
Autoantibodies to ACH receptors on skeletal muscle.
Term
Autoimmune endocrinopathies is the MOA of what dz?
Definition
Type I DM
Term
What group of people are affected by autoimmune diseases of the thyroid?
Definition
Women
Term
What are you prone to in antiphospholipid syndrome? Why?
Definition
-Recurrent thrombosis, fetal loss, and thrombocytopenia.
-antibodies to cardiolipin
Term
What are nonpathogenic autoantibodies used for?
Definition
Marker in Dz
Term
Genetics of autoimmunity can be caused by what?
Definition
Defects in apoptosis gene.
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