Term
| What are the 3 mechanisms of tolerance? |
|
Definition
| Clonal depletion, clonal anergy and t-cell mediated suppression. |
|
|
Term
| What is the most potent costimulatory molecules for peripheral tolerance are? |
|
Definition
|
|
Term
| WHat is the classic example of autoimmunity? |
|
Definition
| Rheumatic heart disease from streptococcal antibodies. |
|
|
Term
| Antibodies to borrelia/Lyme dz attack what target tissue? |
|
Definition
| Synovium, causing Lyme arthritis |
|
|
Term
| What do most pts with Myasthenia gravis have? |
|
Definition
| Autoantibodies to ACH receptors on skeletal muscle. |
|
|
Term
| Autoimmune endocrinopathies is the MOA of what dz? |
|
Definition
|
|
Term
| What group of people are affected by autoimmune diseases of the thyroid? |
|
Definition
|
|
Term
| What are you prone to in antiphospholipid syndrome? Why? |
|
Definition
-Recurrent thrombosis, fetal loss, and thrombocytopenia.
-antibodies to cardiolipin |
|
|
Term
| What are nonpathogenic autoantibodies used for? |
|
Definition
|
|
Term
| Genetics of autoimmunity can be caused by what? |
|
Definition
| Defects in apoptosis gene. |
|
|
