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Definition
| antigen-recognition molecules of B cells |
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Definition
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| major histocompatibility complex |
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Definition
| large cluster of genes. has a cleft running across their outermost surface in which a variety of peptides can be bound |
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Definition
| most abundant immunoglobulin and has several subclasses |
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Definition
| characterized by gamma heavy chains. appears as surface immunoglobulin on mature naive B cells but its function is unknown |
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Definition
| class of immunoglobulin characterized by alpha heavy chains. main antibody class secreted by mucosal lymphoid tissues |
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Definition
| class of immunoglobulin characterized by E heavy chains; involved in the defense against parasite infections and in allergic reactions |
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Definition
| 50kDa (linked together by disulfide bonds) |
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Definition
| 25kDa (linked to a heavy chain by a disulfide bond) |
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Definition
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Definition
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Definition
| two identical fragments that contain the antigen binding activity. they correspond to the two identical arms of the antibody molecule |
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Definition
| fragment containing no antigen-binding activity but was originally observed to crystallize readily (fragment crystallizable= fc) the part of the antibody molecule that interacts with effector molecules and the cells |
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Definition
| a flexible domain that joins the Fab arms to the Fc piece |
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Definition
| three particularly variable segments that can be identified in both the VH and VL domains; denoted HV1, HV2, HV3 |
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Definition
| the regions between the hypervarial region that shows less variability |
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Definition
| found at the surface of the antibody molecule that makes up physical contact with the antigen; they are made up of 6 hypervariable loops |
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Definition
| structure recognized by an antibody |
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Definition
| polypeptide chain linked to TCRB by a disulfide bond |
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Term
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Definition
| polypeptide chain linked to TCRA by a disulfide bond |
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Term
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Definition
| contain two chains: TCR A and TCR b |
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Definition
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Definition
| consist of 2 polypeptide chains: alpha chain; bind short peptides of 8-10 amino acids by both ends |
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Definition
| consists of a noncovalent complex of two chains, alpha and beta, which span the membrane; the length of MHC class II are not restrained |
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Definition
| folded alpha1 and alpha2 domains that form walls of a cleft where the peptide binds |
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Definition
| not polymorphic and is encoded on a different chromosome (chromosome 15) |
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Definition
| is carried by T cells whose function it is to activate other cells |
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Definition
| is carried by cytotoxic T cells |
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Definition
| region of the antibody molecule that engages the effector functions of the immune system (comes in 5 forms) |
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Term
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Definition
| characterized by micro heavy chains. first immunoglobulin to appear on the surface of B cells and the first to be secreted |
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