Term
| Binds cyclophilins, blocks the differentiation and activation of T cells |
|
Definition
|
|
Term
| Immuno drug causing gingivial hyperplasia |
|
Definition
|
|
Term
| 10-100x more potent than cyclosporin |
|
Definition
|
|
Term
| Binds to FK506 inhibiting the release of cytokines |
|
Definition
|
|
Term
| This drug increases effectiveness when given with glucocorticoids |
|
Definition
|
|
Term
| DOC for immunosuppression |
|
Definition
#1 cyclosporin
#2 Tacrolimus |
|
|
Term
| Side effects of cyclosporin |
|
Definition
1.Infection
2. Nephrotoxic
3. Gout
4. Hirsutism
5. Hyperglycemia/Hyperlipidemia
6. Peripheral Neuropathy
7 GINGIVAL HYPERPLASIA |
|
|
Term
| Major Side effect of Tacrolimus |
|
Definition
Nerphrotoxic
Also: HTN, pleural effusion, hyperglycemia, peripheral neuropathy |
|
|
Term
| Binds and inhibits MTOR and decrease T cell proliferation |
|
Definition
|
|
Term
| Sirolimus has reduced toxicity with this organ |
|
Definition
|
|
Term
| Sirolimus is given in combo with |
|
Definition
| Cyclosporin and corticosteroids for Kidney transplants |
|
|
Term
| Monoclonal antibody with high affinity for IL-2R |
|
Definition
|
|
Term
|
Definition
|
|
Term
| Inhibits purine synthesis of nucleic acids |
|
Definition
|
|
Term
| Increased toxicity by allopurinol |
|
Definition
|
|
Term
| Binds to CD3 on T's blocks cell interaction for signal transduction |
|
Definition
|
|
Term
| Used in acute rejection of allografts |
|
Definition
|
|
Term
|
Definition
| Cytokine release syndrome and CI in pregnancy and breast feedin. |
|
|
Term
| Reversible inhibitor of IMP-> blocks de novo formation of GMP |
|
Definition
|
|
Term
| Drug allows dose reduction of cyclosporin |
|
Definition
|
|
Term
| 3 uses of Mycophenolate mofetil |
|
Definition
Dermititis
CT disease
vasculitis |
|
|
Term
| Drug increases absorption with Mg, Aluminum, or cholestyramines |
|
Definition
|
|
Term
| How is Rho-gam administered and why |
|
Definition
| Administered to Rh- mother w/in 72 hours of delivery of a Rh+ delivery to prevent hemolytic dz of newborn in subsequent pregnancies |
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