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Immuno Exam 1 - L7+8
N/A
24
Immunology
Graduate
01/09/2011

Additional Immunology Flashcards

 


 

Cards

Term
primary phago cells in the myeloid system
Definition
neutrophils
Term
process by which cells ingest macromolec in the extracellular tissue
Definition
endocytosis
Term

process by which cells ingest and destory insolube particles such as bacteria, fungi, ect

 

Definition
phagocytosis
Term
4 stages of phago
Definition
chemotaxis, adherence, ingestion, and destruction
Term
two host molec that are responsible for opsonization
Definition
c3b and IgG
Term
Hydrogen peroxide reactions with an enzyme called ____ to form _______
Definition
myeloperoxide, hypohalide ion (OCl-)
Term
molecule released by granules that binds and chelates iron
Definition
lactoferrin
Term
small polypeptides ehich disrupt membrane function and cause osmotic lysis
Definition
defensins
Term
"macrophage activation factor"
Definition
IFN- gamma
Term
hallmark of acute inflam response
Definition
influx of PMN - neutrophils
Term
cardinal signs of inflam
Definition
heat, pain, redness, swelling, loss of function
Term
hallmark of chronic inflam response
Definition
granuloma formation
Term
Main cytokines that induce inflam
Definition
il1,6,8, and TNF - alpha
Term
receptors involved in rolling adhesion
Definition

on endothelium - e-selectin

on leuk - sialyl-lewis

Term
receptors involved in tight binding
Definition

endo - ICAM

cell - Integrins CD11/18

 

Term
receptors involved in diapedesis
Definition

endo - CD#31

cell - integrins

Term
degrade extracellular matrix proteins and regulate actions of cytokines
Definition
matrix metalloproteinases
Term
released by macrophages and attracts and stimulates fibroblasts to repaire damaged tissue
Definition
TGF - beta
Term
name for macrophages withing granulomas with a large amount of cytoplasm
Definition
epithelioid cells
Term
T cell dervied, causes aggregation and fusion of macrophages
Definition
IL4
Term
T cel derived, activates macrophages, inhibits macrophages migration, membrane fusion, and inhibition of matrive metalloproteinases
Definition
IFN - gamma
Term
macrophage derived, stimulates production of proteases involved in removal of extracellular matrix
Definition
IL1
Term
macrophage derived, activates macrophages and stimulates protease production
Definition
TNF-alpha
Term

macrophage derived, stimulates fibroblasts and allows healing of tissues and restructuring of extracellular matrix

 

Definition
TGF - beta
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