Term
| burtons tyrosine kinase deficiency causes |
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Definition
| x-linked agammoglobulinemia which causes prodominent infections |
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Term
|
Definition
| u chain on B cell receptor is replcaced with DJV-delta to make sIgD |
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Term
|
Definition
| if B cell reacts to self antigens apoptosis is initiated. a form of negative selection |
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Term
|
Definition
| when a B cell goes through colonal deletion but passes even though its bad |
|
|
Term
| what cytokines play a role in T dependent antigens and plasma cell antibody production |
|
Definition
| CD40-CD154 and CD 80-CD28 |
|
|
Term
| what happens in a CD40-CD154 deficiency |
|
Definition
| hyper IgM, no class switching, no memory cells |
|
|
Term
| what happens in a CD80-CD28 deficiency |
|
Definition
|
|
Term
| what is the difference between a B1 cell and a B2 |
|
Definition
| B1 express CD5 which is normally on T cells in early embryo, they develop into B2 cells |
|
|
Term
| how is the TCR structured |
|
Definition
| intra and inter disulfide links |
|
|
Term
| what proteins develop on T cells first, while they are still double negative |
|
Definition
glycoproteins except CD4 and CD8
CD44, CD25, some IL-2 receptors |
|
|
Term
| when gamma delta T cells are made, where do they go first second and third |
|
Definition
| first to skin, then to reproductive, then to peripherial and lymphoid tissue |
|
|
Term
| where does RAG 1 and RAG 2 seperate genes |
|
Definition
| regional signal sequence RSS |
|
|
Term
| explain how a B chain is made |
|
Definition
D+J
DJ+V -> B chain protein
DNA ligase combines it with B constant |
|
|
Term
| at what point does the B chain become double positive |
|
Definition
| when B chain goes outside with surogate alpha pTa |
|
|
Term
| how is CD3 structured, what is its function |
|
Definition
| 6 chains, with zeta chain being the main chain in signal transduction |
|
|
Term
| how many times can the B chain rerange |
|
Definition
|
|
Term
| at what point is the gamma and delta locus deleted from the T cell |
|
Definition
| when recombination of the a chain is activated |
|
|
Term
| what activities of positive selection occur in T cell development |
|
Definition
cortex proteins contact thymocytes with MHC I or II to test for self interaction
if MHC I its CD8 and a chains adjust
if MHC II its CD4 and a chains adjust |
|
|
Term
| what negative selection is in T cell development |
|
Definition
| deletion of cells whost antigen receptors bind too strong to self peptides |
|
|
Term
|
Definition
lack of MHC I and or II
lack of or abnormal CD4 or 8 cells |
|
|
Term
| what happens in RAG enzymes are bad |
|
Definition
gene segment recombination issue
bad or no TCR or BCR
omenn syndrome |
|
|
Term
| describe the structure of MHC I |
|
Definition
a1 and a2 make receptor region
a3 is membrane anchor
HLA A, B, C code for different a chains |
|
|
Term
| what does B2 microgloubin do, what is it regulated by |
|
Definition
| folds a chain into binding site, regulated by INF a, b, gamma |
|
|
Term
| what are the genes for MHC II |
|
Definition
|
|
Term
| what regulates MHC II gene expression |
|
Definition
|
|
Term
|
Definition
peptide loading
encodes TAP peptide transporter
encodes LMP2 and LMP7 subunits of proteasome |
|
|
Term
|
Definition
| on serum proteins CD2, CD4, factor B, TNF |
|
|
Term
| explain T cell activation |
|
Definition
| LFA1 or CD4 adherance attaches APC MHCII and TCR and CD28 and CD45 amplify to activate |
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|
Term
|
Definition
| commonly associated with disease like anklyosing spondylitis, reiter's syndrome, acute uvetis |
|
|
Term
| what genes are associated with leporasy |
|
Definition
|
|
Term
| what does a superantigen do |
|
Definition
| connect CD4 B chain on TCR and MHCII on APC making them make IL-1, 6, 8, TNF which cause inflammation |
|
|
Term
| where are early embryonic stem cells or blood islands |
|
Definition
| para-aortic splanchnopleura and aortic-gonad-mesononephron |
|
|
Term
| what is the function of the bone marrow stroma |
|
Definition
| make developmental cytokines and matiration of stem cells |
|
|
Term
| what cells are in a primary follicle |
|
Definition
| B cells, follicular dendritic, macrophages. waiting for antigen contact or die |
|
|
Term
| what cells are in the dark zone of a secondary follicle |
|
Definition
| centeroblasts (b cells that encounter antigen on surface of dendritic cells) only B cells with high affinity to many antigens survive |
|
|
Term
| what cells are in the light zone of secondary follicle |
|
Definition
| centerocytes (B cells that encounter antigen on dendritic cell), some cells undergoing class switching via CD4 |
|
|
Term
| what cells are in the lymph node paracortex |
|
Definition
| Th1 and Th2 mostly, T dependent b cells, antigens and APC, active B cells making antibodies |
|
|
Term
| what cells are in the lymphnode medulla |
|
Definition
| plasma cells, CD8 cells, macrophages |
|
|
Term
| what is in the white pulp |
|
Definition
| periarteriolar lymphoid sheath T cells around central arteriole, primary follicles, secondary follicles with mantle (B cell) and margineal (B/T cell) zones |
|
|
Term
| what antibody is made most in spleen |
|
Definition
|
|
Term
| explain how T cells move into peripherial tissues |
|
Definition
| inflammatory cytokines induce selectin on cell surface, selectin contact with endothelial molecules slowing T cells through venule to target |
|
|
Term
| what molecules are involved with rolling T cell to diapedesis site |
|
Definition
| selectin, ICAM, LFA-1, IL-8 receptor |
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