Term
| Innate Immunity characteristics |
|
Definition
Pre-formed constitutive
Immediate, Non-specific. No memory
Limited Diversity
PRRs and PAMPS |
|
|
Term
|
Definition
Dendritic
Monocytes/macrophages
Granulocytes:
Neutrophils
Eosinophils
Basophils
Mast cells |
|
|
Term
|
Definition
Humoral
Activated by antigen to turn into plasma cells (produce antibodies) |
|
|
Term
|
Definition
Activated by antigen presenting cells and change into:
TH1(CD4): Helps B cells and CTL,
activate macrophages
TH2(CD4): Help B cells
CTL(CD8): Kill infected cells. |
|
|
Term
|
Definition
| Present antigen to T cells in major histocompatibility complexes MHC |
|
|
Term
| Adaptive(acquired) immunity characteristics |
|
Definition
Inducible, Delayed
Clonal selection, Clonal expansion
Specific for antigen, Memory response
Extreme diversity |
|
|
Term
Primary(central)
Vs
Secondary(peripheral) |
|
Definition
Primary:
Bone marrow and thymus
sites where mature lymphocytes develop
Secondary:
Spleen, blood, lymphatic tissue
Sites where immune responses are
induced.
Proliferation, differentiation, action
of lymphocytes. |
|
|
Term
|
Definition
Spleen: Sieves blood borne antigens
periarteriorlar sheath(pals): T cells
Marginal Zone: B cells
Paracortex: T cells.
Cortex: lymphoid follice, B cell zone. |
|
|
Term
| Hematopoietic Stem Cell(CD34) |
|
Definition
Gives rise to lymphoid and myeloid \
progenitor cell.
Lymphoid -> B,T cells. NK cells
Myeloid -> neutrophil, eosinophil ,
basophil, mast cell, dendritic,
macrophage |
|
|
Term
Granulocytes
vs
agranulocytes |
|
Definition
Granulocytes:
Neutrophils, basophils, eosinophils
Agranulocytes: monocytes, lymphocytes |
|
|
Term
Leukocytes(WBCs)
Lymphoid Cells |
|
Definition
Leukocytes: specific and nonspecific
immunity, arise from pluripotent stem
cell in fetal liver and bone marrow
Lymphoid Cells: Major cells of adaptive
system. T cells reside in secondary
lymphoid organs. b cells circulate |
|
|
Term
Mononuclear
vs
granulocytes |
|
Definition
Mononuclear:myeloid lineage: phagocytic
cells. Circulating monocytes migrate
to tissues and mature into macrophage
Granulocytes: Myeloid. Reactive
substances in granules that kill
microorganisms and enhance
inflamation. Mainly innate. |
|
|
Term
|
Definition
Mast cells:contribute to inflammatory
response. Release histamine.
Complement split products -> cause release
Basophils: produce histamine and
herparin, control immune response to
parasites |
|
|
Term
Dendritic Cells
Eosinophils |
|
Definition
Dendritic: Recognize PAMPs and phagocytize pathogens. Present antigens
Eosinophils: Kill antibody coated
parasites and worms by granule release |
|
|
Term
|
Definition
Mast cells: similar to basophils but
reside in tissues and not blood. Expel
parasites through histamine release
NK cells: Kills viral and cancer cells
in much the same way as CD8 cells.
Releases Ifn-y |
|
|
Term
|
Definition
B cells activated by antigen and helped by T cells become plasma cells
High Endothelial venules allow
lymphocytes to enter |
|
|
Term
|
Definition
Lymphocyte: Selectin(L) binds to addressin(CD34) (endothelial)
T cells: Integrin(LFA-1) binds to
ICAM-1 on endothelial
Effector T cells: VLA-4 tto VCAm-1 |
|
|
Term
Zones of spleen
PALS
MArginal Zone
Paracortex
Cortex |
|
Definition
PALS(periarteriorlar sheath): T cells
Paracortex: T cells
Marginal Zone: B cells
Cortex: B cell zone, lymphoid follicle |
|
|
