Term
| a _ stem cell gives rise to immune system cells. it first gives rise to 2 other cells |
|
Definition
pluripotent
common lymphoid progenitor
myeloid progenitor |
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|
Term
| NK cells share their lineage most closely with what other cell of immune system? |
|
Definition
|
|
Term
| common lymphoid progenitor --> ? |
|
Definition
|
|
Term
| common myeloid progenitor --> (6) |
|
Definition
megakaryocyte
RBC
monocyte
eosinophil
basophil
neutrophil |
|
|
Term
| hallmark of HIV infection is decrease in what kind of cells? |
|
Definition
|
|
Term
| reticuloendothelial system 3 roles |
|
Definition
-phagocytosis
-cytokine production to recruit other inflammatory cells
-peptide antigen presentation |
|
|
Term
|
Definition
monocytes
macrophages
dendritic cells
Langerhans cells
glial cells |
|
|
Term
dendritic vs. langerhans cells
--found where? |
|
Definition
|
|
Term
| mast cells are the _ counterparts of _ |
|
Definition
|
|
Term
|
Definition
monocytes
macrophages
neutrophils |
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|
Term
| the first cells recruited to inflammatory sites |
|
Definition
|
|
Term
|
Definition
neutrophils
monocytes
macrophages |
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|
Term
| _ are phagocytes that are big on chemotaxis |
|
Definition
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|
Term
| "professional" antigen presenting cells (3) |
|
Definition
macrophages
dendritic cells
B cells |
|
|
Term
| defense against parasites is by (3) |
|
Definition
eosinophils
basophils
mast cells |
|
|
Term
| eosinophils defend against parasites and participate in _ _ reactions |
|
Definition
| cytotoxic hypersensitivity |
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|
Term
| neutrophils do or don't do antigen presentation? |
|
Definition
|
|
Term
| basophils/mast cells have receptors for _ antibodies |
|
Definition
|
|
Term
| basophils/mast cells have granules that contain (2) |
|
Definition
|
|
Term
| basophils / mast cells degranulate when... |
|
Definition
| cell-bound IgE antibodies are cross-linked by antigens |
|
|
Term
| macrophages are differentiated _ |
|
Definition
|
|
Term
| _ provide a link between innate and adaptive immunity |
|
Definition
|
|
Term
| dendritic cells present antigen to both |
|
Definition
T helper
T cytotoxic cells |
|
|
Term
| B cell class switching from Ig _ to ... is thought to require what cells' assistance? |
|
Definition
IgM --> IgG, IgA, or IgE
T helper cells |
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|
Term
| every mature T cell expresses the _ molecule, (which is associated with the TCR) |
|
Definition
|
|
Term
| ~ are the primary regulators of T cell- and B cell- mediated responses |
|
Definition
|
|
Term
|
Definition
B lymphocytes to become antibody-producing cells
effector T cells in cell-mediated immunity |
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|
Term
| T helper cells express CD _ |
|
Definition
|
|
Term
| T helper cells recognize foreign antigen complexed with ~ |
|
Definition
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|
Term
T helper 1 cells aid in ...
T helper 2 cells aid in ... |
|
Definition
regulation of cellular immunity
B cell production of certain classes of antibodies |
|
|
Term
| T cytotoxic cells are cytotoxic against (2) |
|
Definition
tumor cells
cells infected with intracellular pathogens |
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|
Term
| cytotoxic T cells usu express CD |
|
Definition
|
|
Term
| T cytotoxic cells destroy infected cells in an antigen-specific manner that is dependent upon the expression of ~ molecules on ~ cells |
|
Definition
MHC class I
antigen-presenting |
|
|
Term
| T suppressor cells suppress |
|
Definition
|
|
Term
| T suppressor cells express _ molecules |
|
Definition
|
|
Term
| NKT cells are actually _ cells that share properties of both |
|
Definition
|
|
Term
| NKT cells recognize an antigen presenting molecule _ that binds to ... |
|
Definition
CD1d
self- and foreign
lipids and glycolipids |
|
|
Term
| NK cells nonspecifically kill (2) |
|
Definition
tumor cells
virus-infected cells |
|
|
Term
| NK cells are able to kill _ in the absence of _ _ receptors |
|
Definition
|
|
Term
| _ cells are especially effective against viral infected cells |
|
Definition
|
|
Term
| NK cells secrete _ _ which is an effective immunoregulator |
|
Definition
|
|
Term
| NK cells can kill via ~ using their _ receptors |
|
Definition
|
|
Term
| antigen presenting cells are found primarily in (4) |
|
Definition
| skin, lymph nodes, spleen, thymus |
|
|
Term
| two cells in brain that can do phagocytosis |
|
Definition
|
|
Term
| 10 antigen presenting cells |
|
Definition
monocytes
macrophages
langerhans cells
dendritic cells
B cells
T cells
astrocytes
thyroid follicular cells
endothelium
fibroblasts |
|
|
Term
| antigen-driven proliferation and differentiation take place in _ lymphoid organs |
|
Definition
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|
Term
| B and T cells differentiate from stem cells in _ lymphoid organs |
|
Definition
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|
Term
| T lymphocytes learn to recognize self antigens as self where? |
|
Definition
|
|
Term
| only _ % of maturing T lymphocytes survive and leave the thymus |
|
Definition
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|
Term
| B cells differentiate in the fetal _ |
|
Definition
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|
Term
| B cells differentiate in the adult _ |
|
Definition
|
|
Term
major secondary lymphoid organs; (2)
others include (7) |
|
Definition
spleen
lymph nodes
tonsils
appendix
Peyer's patches
MALT
BALT
GALT
bone marrow |
|
|
Term
| lymph nodes have a _ cell cortex and a _ cell paracortex as well as a central medulla |
|
Definition
B cell cortex
T cell paracortex |
|
|
Term
| lymphoid tissue of spleen is in the _ pulp |
|
Definition
|
|
Term
| white pulp of spleen is arranged around a _ _ as a _ |
|
Definition
central arteriole
periarteriolar lymphoid sheath PALS |
|
|
Term
| within the PALS (specifically, within its _ _) are (2) which present antigen |
|
Definition
dendritic reticular cells
phagocytic macrophages |
|
|
Term
| monocytes are circulating _ precursor |
|
Definition
|
|
Term
| _ cells are responsible for initiation of adaptive responses |
|
Definition
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|
Term
| rank from most to least numerous in blood -- monocyte, basophil, neutrophil, eosinophil |
|
Definition
neutrophil
monocyte
eosinophil
basophil |
|
|
Term
| ...are responsible for adaptive cell-mediated immunity |
|
Definition
|
|
Term
| B cells process and present _ antigens |
|
Definition
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