Term
| Name the 2 primary lymphoid organs. |
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Definition
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Term
| Name the 3 types of progenitor cells and their offspring. |
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Definition
- Lymphoid = T, B, NKs, (some) DC
- Myeloid/Granulocytic = -phils + monos + (some) DC
- CFU-GEMM, Erythroid = RBCs, platelets
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Term
| Name the interleukins for the myeloid and lymphoid lineages. |
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Definition
- Myeloid lineage = IL-3, IL-5, GM-CSF
- Lymphoid lineage = IL-3, IL-7
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Term
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Definition
Antigen capable of eliciting an immune response upon binding.
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Term
| Epitope/Antigenic determinant |
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Definition
Part of antigen that binds Ab/TCR.
Note: Immunogens typically have MANY epitopes. |
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Term
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Definition
Antibody/TCR that binds epitope
Note that paratopes are based on recognition of an antigen by specialized cells of adaptive immunity, not the initial recognition--otherwise Toll-like receptors would have been included here, as well. |
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Term
| Why can't a hapten cause an immunologic response? |
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Definition
Haptens are very small molecules that are just big enough to bind an antibody, but not big enough to bind other antibody sites and therefore cause a cross-reactivity across the cell.
Immunogens are complex antigens that have repetitive antigens that can cross-link several paratopes. |
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Term
| When can a hapten cause an immune response? |
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Definition
| ONLY when they are covalently linked/conjugated to carriers, immunogenic proteins that can bind all the haptens so they cross-link. |
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Term
| What is the immune response to hapten-carrier conjugates? |
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Definition
ANTIBODIES--made against hapten + carrier
T CELLS--only recognize carrier |
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Term
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Definition
| Molecule that can bind to a paratope but NOT cause an immunologic response. |
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