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Immune System - T Cell Mediated Immunity
Dr Casiano 12/6/10
31
Medical
Professional
12/06/2010

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Cards

Term

 

- this process ensures that immature T cells can recognize antigens via TCR-MHC interactions

- this process only includes self-antigen presentation

- weak binding=death

Definition

 

Positive Selection

Term

 

- process that eliminates self-reactive T cells in the thymus

- strong reaction = death

 

Definition

 

Negative Selection

Term

 

- most of the self-antigens presented in the thymus are derived from these

Definition

 

dying thymocytes (apoptosed)

Term

 

- this transcription factor provides a vital function by turning on genes for samples of tissue-specific antigens for the T cells to be "tested" on

Definition

 

Autoimmune regulator (AIRE)

Term

- this trait allows dendritic cells to be very good APC's
Definition

 

Movable from periphery to secondary lymphoid organs

Term

 

- the Dendritic cells capture pathogens by this method before presenting them to CD4 T cells via MHC Class II molecules

Definition

 

receptor-mediated endocytosis

Term

 

- the name for the process by which Dendritic cells ingest pathogens that are not recognized by receptors

Definition

 

Macropinocytosis

Term

 

- viral proteins are presented via this Class of MHC

Definition

 

MHC Class I

Term

 

- these develop on dendritic cells in the lymph nodes are what is used to classify them as "mature" or "activated"

Definition

 

dendrites (interaction sites for T cells)

Term

 

- site of T cell and dendritic cell interaction

Definition

 

lymph node (paracortex)

Term

 

- T cells express this surface protein that helps them bind to the chemokine gradient that brings them to the secondary lymphoid organ (homing)

Definition

 

CCR7

Term


- chemokines that bind CCR7 and take part in the chemokine gradient that guides T cell movement

Definition


CCL19 & CCL21

Term

 

- these cell-adhesion molecules are expressed on the T cell surface and allow for binding to the CAMs on the vascular endothelium leading into the secondary lymphoid orgran

Definition

 

selectin and LFA-1

Term

 

- these surface molecules appear on endothelium and coupled with the cell-adhesion molecules on T cells help facilitate the T cell enter into secondary lymphoid organs (lymph nodes)

Definition

 

CAMs (CD34, GlyCAM-2, ICAM1/ICAM2)

Term

 

- the term used to describe the T cell movement from the blood to the lymph node via the endothelium (HEVs)

Definition

 

Diapedesis

Term

 

- the first signal of two required for T cell activation

Definition

 

ligation of TCR with peptide/MHC complex on Dendritic cell

Term

 

- the second signal required for T cell activation requires these co-stimulatory molecules

Definition

 

B7 molecules

Term

 

- in addition to production or availability of the co-stimulatory molecules required to activate T cells the T cell-APC interaction requires this binding to stabilize it

Definition

 

LFA-1 (T cell surface) to ICAM (on DC surface)

Term

 

- the surface molecule on the T cell is required to recognize B7 molecules during the co-stimulatory action of T cell activation

Definition

 

CD28

Term

- the intracellular domain that initiates signal transduction after TCR-MHC binding, CD3 activation, and phosphorylation of this domain
Definition

 

ITAM (immunoreceptor tyrosine-activation motif)

Term

 

- the intracellular protein kinase that phosphorylates the ITAM leading to an activation of the proliferation/survival pathway

Definition

 

ZAP-70

Term

 

- after phosphorylating SLP-76, SLP67, ItK, GADS, and LAT, the proliferation/survival pathway phosphorylates these two molecules that induce subsequent changes (previous knowledge from physio)

Definition

 

PLC (phospholipase C)

GEF

Term

 

- this cytokine is released by macrophages and assists in activating T cell proliferation

Definition

 

IL-1

Term

 

- after activation the T cells express a high affinity of this cytokine receptor in addition to secreting this cytokine themselves

Definition

 

IL-2

Term

 

- T Helper 1 cells secrete these cytokines that activate T cells, NK cells, and macrophages primarily against viruses and bacteria

Definition

 

IL-2, interferon, tumor necrosis factor B

Term

 

- T Helper 2 cells secrete IL-4, IL-5, Il-10, IL-13 that switch Ig to IgE and induce eosinophil activation which acts primarily in response to these

Definition

 

allergens and parasites

Term

 

- these two membrane-bound receptors facilitate activation-induced cell death on most activated T cells

Definition

 

Fas & Fas ligand

Term

- the T cells that do not undergo activation-induced cell death become these
Definition

 

memory T cells

Term

 

- CD8+T cells are activated by these two factors, one of which is made by CD4 T cells and internally

Definition

 

B7 (CD80) and IL-2

Term

 

- the signaling pathways activated by the ITAM pathway that are required for division

Definition

 

NGkB, NFAT, AP-1

Term

 

- the "weapons of mass destruction" that the CD8+ T cells use to kill the APC

Definition

 

perforin, cytotoxic granules (granzymes), &

Fas receptor/Fas Ligand

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