Term
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Definition
reaction to an antigen
requires initial exposure, followed by subsequent exposures
progressively hypersensitizes host
uncomfortable,adverse, sometimes fatal
Four types |
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Term
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Definition
failure to recognize "self"
75% are women, antigenic mimicry
cause inflammation, tissue damage, pain, death
ie: Type 1 diabetes, MS, RA, IBS |
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Term
| Immunodeficiency disorder |
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Definition
| deficiency in the immune response |
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Term
Type 1 Hypersensitivity
IgE mediated anaphylactic reactions |
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Definition
involves mast cells, basophils, and cell mediators
systemic or localized
can produce shock
ie: allergies to food and insects, asthma |
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Term
Type 2 Hypersensitivity
Cytotoxic Hypersensitivity |
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Definition
involves igG, IgM, complement, destruction of host cell
ie: incompatible blood types, Rh factor |
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Term
Type 3 Hypersensitivity
Immune Complex Hypersenitivity |
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Definition
antibodies combine with antigens
creates aggregates
accumulate in vessels or on tissue surfaces
cause inflammation and clots |
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Term
Type 4 Hypersensitivity
Delayed Cell-Mediated |
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Definition
involves T cells
not an immediate reaction
causes skin reaction
ie:poison ivy, metals in jewelry |
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Term
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Definition
| graft taken from one part of body and transplanted to anthoer part of the same body |
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Term
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Definition
| grafts between identical twins |
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Term
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Definition
| grafts between members of the same species |
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Term
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Definition
| grafts between two different species |
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Term
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Definition
| an antigen that causes hypersensitivity |
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Term
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Definition
1. Mutation-affect cell division and apoptosis
2. Body sites normally sequestered become accessible during injury
3. Antigenic Mimicry-foreign antigen resembles a body substance causing attack of "self" |
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Term
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Definition
| dependent on MHC proteins-the closer the match, the greater chance of success |
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Term
| HLA Complex (Human Leukocyte Antigen) |
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Definition
set of genes responsible for production of MHC proteins different people have different genes
Important role in transplants |
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Term
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Definition
Major histocompatibility complex
play a roll in natural killer cell reactions and display of antigens to T cells |
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