Cyclosporine

Injection,oral solution, cap

Cyclosporine

oral solution

cap

Tacrolimus

injection

cap

cyclosporine

tacrolimus

cyclosporine

adverse effects

• gingical hyperplasia
• HTN
• Hepatotoxicity
• nephrotoxicity
• DM
• Hyperkalemia
• hypomagnesemia
• hirsutism
• acne

tacrolimus

adverse effects

• alopecia
• HTN
• Hepatotoxicity
• DM
• Hyperkalemia
• hypercalcemia
• hypomagnesemia
• anemia

Cyclosporine

Drug-disease interaction

• Altered bilary flow:need bile acid to be absorbed
• DM
• live Vaccine should be avoided

Tacrolimus

drug-disease interaction

• DM
• live vaccine
• Does not require bile acid for absorption

sirolimus

mTOR inhibitor

Sirolimus

drug-disease interaction

• In de novo liver transplant recipients
• in de novo lung transplant recipoents
• life vaccines should be avoided

sirolimus

adverse effects

• anorexia
• nephrotoxicity with calcineurin inhibitors(cyclosporine, tacrolimus)
• Hyperlipidemia
• HTN
• Hyperkalemia
• acne
• thrombosis
• pneumonitis

Azathioprine

antiproliferative agents

Mycophenolate mofetil

antiproliferative agents

Leflunomide

antiproliferative agents

Azathioprine

drug-drug interactions

allopurinol

Xanthine oxidase

Mycophenolate mofetil

drug-drug interaction

cyclosporine

alters enterohepatic recycling

Leflunomide

drug-drug interactions

cholestyramine

active chacoal

leflunomide

adverse effects

• alopecia
• DM
• diarrhea
• anorexia
• hyperlipidemia
• hyperthyroidsm
•  

Methylprednisolone

dexamethasone

prednisone

prednisolone

Basiliximab

25% murine chimeric

Daclizumab

humanized

Basiliximab

Daclizumab

MOA

monoclonal IgG

binds to the a subunit, CD25, activates IL-2

antithymocyte globulin

equine

rabbit

anti-thymocyte globulin

rabbit