Term
| Major Histocompatibility Complex (MHC) |
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Definition
| Proteins on the surface of tissue and blood cells, commonly referred to as Human Leukocyte Antigens (HLA), found on all nucleated cells in the body, play a pivotal role in the development of humoral and cellular immunity. |
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Term
| What is the main function of Major Histocompatibility Complex (MHC)? |
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Definition
| Bring an antigen to the cell surface for recognition by T cells, only when an antigen is combined with MCH molecules does T cell activation occur, Second only to ABO antigens in influencing the survival or rejection of transplanted organs. |
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Term
| What are the two classes of MHC? |
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Definition
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Definition
| Molecules can be found on the surface of most nucleated cells in the body. |
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Definition
| Molecules are only found on certain cells associated with the immune system such as monocytes, macrophages, and some tumor cells. |
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Definition
| MHC regulates the specific immune response through a MHC restriction, refers to the fact that T-cells will only recognize an antigen bound to a certain MHC molecule. |
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Definition
| Can interact with antigens bound to the MHC class II molecules on the surface of APCs. They then activate B-Lymphocytes. |
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Definition
| only interact with antigens bound to the MHC class I molecules, usually on the surface of virally-infected cells. |
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Definition
| the process in which particulate antigens aggregate to form larger complexes in the presence of a specific antibody. |
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| The combination of soluble antigen and antibody to form insoluble complexes that are visible. |
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| involves antigen and antibody with a cellular indicator (lysed RBCs) |
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Definition
| measurements of the immune complexes formed in an invitro system. |
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