Term
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Definition
| is a heat-labile series of 18 plasma proteins. Plays a major role in the inflammatory response directed against foreign antigens. |
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Term
| Are complement system plasma proteins normally present in the blood? |
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Definition
| Yes, in an inactivated state. |
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Term
| When activated, plasma proteins proceed in a cascading sequence that results in ________ _________. |
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Definition
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Term
| What are the two Complement System Pathways? |
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Definition
Classical Pathway
Alternate Pathway |
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Term
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Definition
| The main antibody-directed mechanism for triggering complement activation. Involves 9 proteins, called components, and are viral neutralizers, activated by IgM, IgG1, IgG2, & IgG3. IgA, D, & E do NOT bind complement. |
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Term
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Definition
| As enzyme activity is generated, the active protein complex is called convertase, because it converts the next protein in the sequence into the active form. |
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Term
| Why is IgM the most efficient activator of complement? |
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Definition
| it has multiple binding sites (pentamer) |
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Term
| How many IgG molecules are required to activate complement? |
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Definition
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Term
| What are the three phases of the Classical Pathway? |
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Definition
| Recognition, Activation, and Membrane Attack Phase. |
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Term
| What is the main difference between the classical pathway and the alternate pathway? |
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Definition
| The alternate pathway does not need an antigen/antibody complex in order to activate pathway. |
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Term
| How is the Alternate Pathway activated? |
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Definition
| by contact with polysaccharides found on the surface of such foreign substances or cells as bacteria, fungi, viruses, & tumor cells. |
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Term
| What are the effects of complement activation? |
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Definition
| Blood vessel dialation, increased vascular permeability. |
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Term
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Definition
| Foreign substances coated with complement, renders cells vulnerable to phagocytosis. |
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Term
| Specific Control Proteins (complement) |
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Definition
C1 inhibitor
Factor I
Factor H
Protein S |
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