Term
methotrexate
metoprolol
probenecid |
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Definition
interaction: methotrexate-probenecid
effect: combination may increase methotrexate levels, risk of toxicity
mechanism: renal excretion is decreased |
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Term
enalapril
amiodarone
warfarin |
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Definition
interaction: amiodarone-warfarin
Effect: increased anticoagulant effect and risk of bleeding
Mechanism: amiodarone inhibits warfarin metabolism |
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Term
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Definition
interaction: fluconazole - warfarin
effect: increase INR, risk of bleeding
mechanism: hepatic metabolism inhibited
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Term
amoxicillin
cyclosporine
St. John's wort |
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Definition
interaction: cyclosporine - St. John's wort
effect: decreased cyclosporine levels and efficacy; acute transplant rejection, and graft loss
mechanism: GI hepatic metabolism induced, gut P-glycoprotein induced |
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Term
itraconazole
hydrochlorothiazide
lithium |
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Definition
interaction: lithium - hydrochlorothiazide
effect: increased lithium levels, risk of toxicity, (weakness tremor, excessive thirst, confusion)
mechanism: renal excretion decreased
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Term
cholestyramine
hydrochlorothiazide
levothyroxine |
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Definition
interaction: 1) levothyroxine - cholestyramine
2) hydrochlorothiazide-cholstyramine
effect: 1) decreased thyroid hormone efficacy
2) decreased thiazide levels (give thiazide either 1hr before or 4-6 hours after)
mechanism: 1 & 2) absorption is decreased |
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Term
fluoxetine
tranylcypromine |
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Definition
interaction: above
effect: CNS toxicity or serotonin syndrome (htn, hyperthermia, myoclonus, mental status changes); neuroleptic malignant syndrome
mechanism: additive/ synergistic effects
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Term
isosorbide mononitrate
sildenafil |
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Definition
interaction:
effect: potentiation of hypotensive effects; cardiovascular collapse
mechanism: synergistic effects
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Term
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Definition
interaction:
effect: increased repaglinide levels; risk of hypoglycemia; other adverse effects
mechanism: hepatic metabolism inhibited
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Term
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Definition
ACEi - used in htn and heart failure
(no drug interaction) |
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Term
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Definition
anti-arrhythmic drug (used in cardiac arrhythmias)
(1 drug interaction - with warfarin) |
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Term
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Definition
oral anticoagulant
(2 drug interactions: amiodarone and fluconazole) |
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Term
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Definition
folic acid antagonist (anticancer drug, immunosuppressant)
(1 drug interaction - with probenecid) |
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Term
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Definition
beta-adrenegic blocker
(no drug interaction) |
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Term
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Definition
uricosuric drug; example of use= tx for gout
(1 drug interaction - with methotrexate) |
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Term
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Definition
antifungal
(1 drug interaction - with warfarin) |
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Term
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Definition
immunosuppressant
(1 drug interaction - St. John's wort) |
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Term
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Definition
dietary supplement; example of use - tx of depression
(many drug interactions - 1 here - cyclosporine) |
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Term
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Definition
antifungal
(1 drug interaction - w/ repaglinide) |
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Term
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Definition
diruretic
(two drug interactions: with lithium and cholestyramine) |
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Term
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Definition
mood-stabilizing drug
(1 drug interaction - with HCTz) |
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Term
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Definition
bile acid-binding resin
(2 drug interactions - with HCTz and with levothyroxine) |
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Term
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Definition
thyroid agent
(1 drug interaction - with cholestyramine) |
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Term
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Definition
antidepressant
(1 drug interaction) |
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Term
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Definition
monoamine oxidase inhibitor
(1 drug interaction) |
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Term
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Definition
antianginal drug
(1 drug interaction) |
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Term
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Definition
drug for erectile dysfunction
(1 drug interaction) |
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Term
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Definition
insulin secretagogue
(1 drug interaction) |
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