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ICM- Hematology and Oncology
Coagulation Cascade (T Pierce)
4
Medical
Professional
11/18/2009
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Term
vascular factors of arterial circulation
 Definition
  • high flow
  • muscular vessels
  • high pressure
  • blood loss massive
  • platelets critical for rapid response
  • clotting secondary, but important
    • affected by antiplatelet agents moreso (ex: ASA for coronary thrombosis)
Term
vascular factors affecting normal hemostasis of venous circulation
 Definition
  • low flow
  • nonmuscular vessels with valve system
  • slower blood loss
  • platelets not very important
  • rate of thrombin generation critical
    • anticoagulants (ex: heparin) for pulmonary embolism
Term
balance of factors on procoagulant and antcoagulant factors
 Definition
  • procoagulant and anticoag
    • vascular factors
    • platelet factors
    • soluble clotting factors vs. soluble inhibitors
    • fibrinolytic inh. vs. pro-fibrinolytic factors
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