Term
| esential nutrients of erythropoiesis |
|
Definition
- iron
- cobalamin
- folic acid
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Term
| folic acid (enzyme, function, source, absorption, storage) |
|
Definition
- thymidylate synthetase
- function in DNA synthesis
- found in vegetables, fruit liver
- absorbed at proximal intestines
- stored in liver
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|
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Term
| cobalamin (enzyme, func, source, absorption, storage) |
|
Definition
- methionine synthetase
- function- DNA synthesis
- source- meat, milk, egg
- absorption- terminal ilium
- storage- liver, kidney
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|
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Term
| iron (enzyme, function, source, absorption, storage) |
|
Definition
- ferrochelatase
- function- Hb syn.
- source- meat, fortification
- absorbed in prox. intestines
- storage- macrophages
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Term
|
Definition
- oxygen carrrying ion part of heme group
- exists as ferrous or ferric state, but only ferrous can bind oxygem
- heme- made of porphyrin and iron
- Hb- made of four globular protein subunits and with heme
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Term
| roles of iron as a nutrient |
|
Definition
- reversible oxygen binding- Hb, Mg
- enzyme
- heme (cytochromes)
- iron sulfure cluster (aconitase)
- ribonucleotide reductase
- immunity- free radicals to destroy microbes
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|
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Term
| causes of iron deficiency |
|
Definition
- chronic blood loss
- GI bleed (carcinoma, ulcers, diverticuli, A-V malformation, hookworm)
- dietary insufficiency
- rapidly growing kids
- women of child bearing age
- malabsorption
- s/p gastrectomy
- s/p resection prox. small bowel
- crohn's disease
- celiac disease
- pregnancy and lactation
- hemoglobinuria
- secondary to intravascular hemolysis
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