FSH Analog- recombinant form of FSH

Recombo LH

Used only in combo w/Follitropin Alpha to stim follicle development in severe LH deficiency or infertility

S.C. or IM

-Stimulate ovulation secondary to hypogonadism, PCOS, obesity in women who fail other treatments

-controlled ovarian hyperstimulation assist reproduction

-treat male infertility with hypogonadism

HA

Depression

Edema

Ovarian hyperstimulation syndrome

multiple pregnancies

gynecomastia in men

Long half life GnRH synthetic

Occassionally stimulate gonadotropin release

More often to suppress gonadotropin release

-controlled ovarian hyperstimulation

-endometriosis

-uterine fibroids

-prostate cancer

-central precocious puberty (age 8F;9M)

iv q 1-4 hrs

pulsatile GnRH release..LH,FSH release

Continuous admin..

inc hormones 7-10 days... then prolonged INH response

HA, lightheaded

NA

Flushing

Rare acute hypersens rxn

Long term women:

-menopausal sx

-ovarian cysts

-dec bone density

CI: pregnancy, breastfeed

Long-term men:

androgen deprivation

-gynecomastia, hot flash, sweats, dec bone density

Long-term kids:

well tolerated

"relix"

example: Ganirelix

SC or IM

Inhibits LH and FSH secretion in dose-dependent manner

controlled ovarian hyperstim

-better than Agonists because no initial surge

advanced prostate cancer

-better than Agonists because no initial surge

Nausea

Headache

Abarelix only: immediate onset allergic rxns

-skin, hypotension, syncope, sx androgen depriv (flush, sweats)

T4 drug of choice

Long t1/2

low cost

lack allergic response

T4 -> T3 in cells

treat hyperthyroid

thioamide

MOA: Inhibits hormone synthesis and block iodine organification (slow onset)

Radioactive Iodine Uses

thryotoxicosis

beta rays destroy part of thyroid gland. 

Adjunct w/BB

<POSTerior Pituitary>

Initiate Labor

control postpartum bleed

ADH analog (pee LESS)

longer t1/2

selectivity V2 rec

ADH ANTagonist

(pee MORE)