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Hypothalamus
Neuro
64
Biology
Undergraduate 4
11/30/2011

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Term
Hypothalamus
Definition
-autonomic nervous system activity and endocrine receptors
-regulates behaviors related to survival
Term
Four "F"S
Definition
fighting, feeding, fleeing, mating
Term
Contextual info-->Hypothalamus<--Sensory Inputs
|->?
Definition
Visceral motor, somatic motor, neuroendocrine behavioral response
Term
Contextual info
Definition
cerebral cortex, amygdala, hippocampal formation
Term
Hypothalamus
Definition
compare input to biological set points
Term
Sensory inputs
Definition
visceral and somatic sensory pathways
Term
Nucleus of the solitary tract
Definition
-main input of hypothalamus
-receives sensory infer from the vagus nerve
Term
Reticular formation
Definition
-main input of hypo
-receives inputs from spinal cord (ex: spinoreticular)
Term
Retina
Definition
-main input of hypo
- some fibers of the optic nerve project directly to the suprachiasmatic nucleus for entrainment of circadian rhythms
Term
Limbic and olfactory systems
Definition
the amyglada, hippocampus, and olfactory cortex project to the hypothalamus
Term
Anterior pituitary
Definition
-neuroendocrine cells in the hypothalamus secrete releasing factors into the hypothalmo-hypophoseal portal system
-releasing factors travel to anterior PG
- cells in the PG release hormones into the blood
Term
6 hormones the Anterior PG releases
Definition
adrenocorticotropic hormone, thyroid stimulating, follicle stimulating, lutienizing hormone, prolactin, growth hormone
Term
Posterior pituitary
Definition
-neuroendocrine cells in the hypothalamus
-neuroendocrine cells project down the hypophyseal stalk to the posterior pituitary gland
-hormones made in the hypothalamus are released directly in peripheral circulation (oxytoxcin, vasospression)
Term
Lesions of ventromedial nucleus/medial hypothalamus
Definition
obesity, excitability
Term
Lesions in lateral hypothalamus
Definition
aphagia, placidity
Term
Lesions in Anterior hypothalamus/preoptic
Definition
hyperthermia
Term
Lesions in posterior hypothalamus
Definition
hypothermia in cold
Term
lesions preoptic area, organum vasculosum of the lamina terminals, subfornical organ
Definition
abnormal thirst
Term
Lesions in paraventricular and supraoptic
Definition
diabetes inspidus
Term
Pituitary gland connected to hypo by?
Definition
hypophyseal stalk
Term
PG located?
Definition
outside BBB
Term
PG releases hormones..
Definition
directly into the blood
Term
Two lobes
Definition
anterior (adenohypohysis)
posterior (neurohypophysis)
Term
Two major outputs
Definition
neural signals to the autonomic system
endocrine signals to/through the pituitary
Term
Neural signals to the autonomic system
Definition
-lateral hypothalamus projects to the lateral medulla
-vagal nuclei and other descending systems that control heart rate, vasoconstriction, sweating, digestion
Term
Endocrine signals
Definition
-magnocellular neurons in paraventricular nucleus and supraoptic nucleus secrete oxytocin and vasopression directly into blood steam
Term
Hypothalamic regulation of the gonads (basic pattern is the same for males and females)
Definition
CNS-->hypothalamus-->Anterior PG-->gonads
Term
Male and female differences
Definition
-pattern of LHRH, LH and FSH release
-pattern and quantity of steroid hormone production
-sensitivity of the hypothalamus to feedback signals
Term
Dimorphic behaviors
Definition
-more diverse then copulation
-courting, care, nest building, young, grooming, aggressions
Term
SRY Gene on Y chromosome
Definition
induces development of testis
Term
Testes secrete..
Definition
anti-mullerian hormone (defeminizing effect)
Term
Androgens
Definition
stimulate Woliffian system developmenet
Term
Role of alpha fetaprotein
Definition
blocks action of circulating estrogens - prevents estrogen from getting through BBB of mother during pregnancy
Term
Mullerian system
Definition
fallopian tubes, uterus, 2/3 of vagina
Term
Wolffian system
Definition
epididymis, vas deferens, seminal vesicles
Term
Regression of Mullerian ducts
Definition
defeminization
Term
Development of Wolfian ducts
Definition
masculination
Term
external male reproductive structures require
Definition
dihydrotesterone (DHT)
Term
9 weeks: Presence of SRY gene
Definition
developing glans of penis, urethral groove, fused urogenital folds
Term
9 weeks: NO SRY
Definition
developing glans clitoris, urethral groove
Term
Mullerialian inhibiting substance
Definition
Testosterone - external urethral office, body of penis, scrotum
Term
12 weeks no SRY
Definition
clitoris, urethral orifice, vagina
Term
In both male and females, the onset of puberty is a brain event.....
Definition
before it is a reproductive event
Term
transition from non reproductive to reproductive state
Definition
maturation of the hypothalamo-pitutary gondal axis
Term
Anatomical nervous system changes in male and females due to gonadal steroids (especially testosterone)
Definition
Total brain size, hypothalamus, spinal cord, corpus callosum, finger length, otoacustic emissions
Term
Spinal nucleus of the bulbocavernosus
Definition
In females, muscles involved with erection and urination - neurons degenerate, apoptosis of these muscle cells
Term
In men
Definition
T induces apoptosis of bulbocavernosus muscles soon after birth - neurons die as a result of loss of trophic support
Term
Amygdala and emotional memory
Definition
amygdala activity cause women to be more likely to retain details of an emotional event and men more likely to remember the gist
Term
Acute Stress
Definition
caused the density of dendritic spines in the hippocampus to increase in the male brain but decrease in female brain
Term
Chronic Stress
Definition
may leave the male hippocampus more vulnerable to harm
Term
Genetic Sex
Definition
what chromosomes you have
Term
Gonadal Sex
Definition
what reproductive organs you have
Term
Phenotypic sex
Definition
what you look like, secondary sex characteristics
Term
Sexual identity
Definition
who you think you are, who you chose to mate with
Term
legal sex
Definition
what society says you are
Term
early androgen exposure promotes
Definition
behavioral defeminization as an adult
behavioral masculinization
involves estrogen receptors
Term
Congenital adrenal hyperplasia (CAH)
Definition
XX fetus
adrenal hyperactivity results in excess testosterone production
fetal/neonatal brain is masculinized
Term
Androgen insensitivy syndrome
Definition
XY fetus
testis make testosterone but cells of body cannot respond to it
Term
Prenatal hormone exposure may play a role in sexual orientation
Definition
CAH results in exposure of female fetus to high levels of androgens
Term
What area is involved in control of male sexual behavior
Definition
medial preoptic area
Term
MPA contains
Definition
testosterone receptors
Term
MPA neurons are active during
Definition
copulation
Term
MPA receives input from
Definition
the vomeronasal organ
Term
MPA has outputs to the motor neurons of the
Definition
spinal cord that control pelivic organs involved in copulaton
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