Shared Flashcard Set

Details

Hypothalamic and Pituitary Hormones
Pharmacology of hypothalamic and pituitary hormones
15
Pharmacology
Professional
04/26/2011

Additional Pharmacology Flashcards

 


 

Cards

Term
What is somatropin? How is it made? Clinical applications? Tox?
Definition
recombinant GH. Replacement in GH deficiency, for increased adult height in children with certain conditions associated with short stature, wasting in HIV syndrome, short bowel syndrome. Scoliosis, edema, gynecomastia, intracranial HTN, myalgia, arthralgia, CTS, increased CYP activity
Term
What is mecasermin? Clinical applications? What does it also contain? Why? Tox?
Definition
recombinant IGF-1. Replacement in IGF-1 deficiency that is not responsive to exogenous GH. Recomb ICGBP-3 to prolong half-life. Hypoglycemia, intracranial HTN, increased liver enzymes
Term
What is octreotide? What are its effects? Clinical applications? Tox? How does lanreotide differ?
Definition
Somatostatin analog, inhibits production of GH and to a lesser extent of glucogon, insulin and gastrin. Acromegaly and several other hormone-secreting tumors, acute control of bleeding esophageal varices. GI disturbances, gallstones, bradycardia, other cardiac probs. Lanreotide is long-acting for acromegaly.
Term
What is pegvisomant? Clinical applications? Tox?
Definition
GH receptor antagonist (blocks GH receps), acromegaly, increased liver enzymes
Term
What are menotropins?
Definition
extract of the urine of postmenopausal women that contains FSH and LH
Term
What are the toxic effects of FSH and LH analogs? Which is used for infertility due to hypogonadism in men?
Definition
Ovarian hyperstimulation syndrome and multiple pregnancies in women, gynecomastia in men, headache, depression and edema in both sexes. FSH.
Term
What is leuprolide? What happens with prolonged continuous administration? Clinical applications? Toxicity?
Definition
GNRH analog, decreases LH and FSH secretion instead of increasing it. Ovarian suppression, controlled ovarian hyperstimulation, central precocious puberty, advanced prostate cancer. HA, light-headedness, nausea, injection site reactions, hypogonadism with continuous treatment
Term
What are goserelin, histrelin, nafarelin, and triptorelin?
Definition
GNRH analogs
Term
What is ganirelix? What are the effects? Clinical applications? Tox
Definition
GNRH receptor antagonist, reduces production of LH and FSH. Prevention of premature LH surges during controlled ovarian hyperstimulation. Nausea, HA.
Term
What is cetrorelix? What is it approved for?
Definition
GNRH receptor antagonist, controlled ovarian hyperstimulation
Term
What are abarelix, degarelix? What are they approved for? What type of reactions can they cause?
Definition
GNRH receptor antagonists, advanced prostate cancer, immediate-type hypersensitivity reactions
Term
What is bromocriptine? Clinical applications? Tox? What is another drug of this class with similar effects?
Definition
dopamine agonist, activates D2 receps, for tx of hyperprolactinemia and parkinson's disease. GI disturbances, orthostatic hpotension, HA, psych disturbances, vasospasm and pulm infiltrates in high doses. cabergoline.
Term
What is atosiban? Clinical applications? Tox?
Definition
oxytocin recep antagonist, toxolysis for preterm labor, concern about rates of infant death.
Term
What is desmopressin? What receps does it preferentially activate? Clinical applications? Tox?
Definition
vasopressin receptor agonist, V2 more than V1. DI, hemophila A and VWD. GI, HA, hyponatrmia, allergic
Term
What is conivaptan? Clinical application? How does tolvaptan differ?
Definition
antagonist of vasopressin V1a and V2 receptors, hyponatremia in hospitalized pts. Similar but more selective for V2 receps.
Supporting users have an ad free experience!