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Hypertension
N/A
51
Pharmacology
Undergraduate 2
07/09/2013

Additional Pharmacology Flashcards

 


 

Cards

Term
What is the formula for finding BP?
Definition

BP=rate x volume x resistance

 

Term
What is chronotropy?
Definition
Speed of the heart beat
Term
What is inotropy?
Definition
Muscle strength of contractility
Term
What affects blood volume?
Definition
kidneys: diuretics
Term
What are 3 types of diuretics?
Definition
Thiazids > K+ sparring > loop diuretics
Term
What is the formular for finding the mean arterial pressure (MAP)?
Definition
MAP=2/3(DBP) + 1/3(SBP)
Term
What affects resistance?
Definition
vasculature (blood vessels): vasodilation, vasoconstriction
Term
What is normal BP?
Definition

systolic: <120

AND

diastolic: <80

Term
What is the measure of prehypertension?
Definition

systolic: 120-139

OR

diastolic: 80-89

Term
What is the BP of stage 1 HTN
Definition

systolic: 140-159

OR 

diastolic: 90-99

Term
What is the BP for stage 2 HTN?
Definition

systolic: >160

OR 

diastolic: >100

Term
What is the BP of HTN crisis?
Definition

systolic: >180

OR

diastolic: >120

Term
What is the BP goal for most adult patients?
Definition

systolic: <120

diastolic: 90

Term
Symptoms of hypotension
Definition
dizziness, light headedness (usually upon standing suddenly)
Term
What is the MOA of BB?
Definition

reverse/block adrenergic effects at beta receptors 

B1: decreases SA node heart rate, slows AV node conduction, decreases cardiac contractility

 

Term
precautions using BBs
Definition
bradycardia, asthma, diabetes, depression
Term
What are the B1 selective BB meds? (2)
Definition

Atenolol

Metoprolol

Term
What is the one non-selective BB med?
Definition
Propanolol
Term
What are the 2 alpha and BB meds?
Definition

Labetalol

Carvedilol

Term
What are the two types of CCBs?
Definition
DHPs and non-DHPs
Term
What is the use of DHP?
Definition
lower BP
Term
What is the use for non-DHP?
Definition
decrease HR
Term
precautions using non-DHP CCBs
Definition
bradycardia, heart failure, hypotension, constipation
Term
What are the 2 non-DHP meds?
Definition
verapamil and diltiazem
Term
What does Ca+ do to vascular smooth muscle?
Definition
depolarization/contraction of muscle
Term
precautions of using DHP CCBS?
Definition
reflex tachycardia, peripheral edema, heart failure
Term
diuretics MOA
Definition

1.) manipulation of salf concentration in renal filtrate

(alters water volume excretion)

2.) potency of diuretic depends on location in renal nephron

Term
What are the 3 locations in the renal nephron that diuretics act upon?
Definition
loop of henle>>distal tubule>>collecting duct
Term
Name the 3 diuretics from strongest to weakest
Definition
loop diuretics>>thiazids>>K+ sparring
Term
What are the 2 DHP meds?
Definition

1.)amiodipine

2.)felopdipine

Term
Loop diuretics MOA
Definition

1.)inhibits reabsorption of Na+/Ca+

2.) increases water inside tubule to be excreted

 

Term
precautions using loop diuretics
Definition
electrolyte disturbances, hypovolemia, sulfa allergy, ototoxicity
Term
Thiazides MOA
Definition

inhibits reabsorption of Na+/Ca+

(to increase water to be excreted)

Term
Uses of thiazides
Definition
First line treatment of HTN
Term
precautions using thiazides
Definition
renal dysfunction, electrolyte disturbances, diabetes, hypersensitivities
Term
K+ sparring diuretics MOA
Definition
increases Na+ excretion and K+ reabsorption from urine
Term
precautions of K+ sparring diuretics
Definition
hyperkalemia and gynecomastia (abnormally large breasts in males)
Term
Loop med (1)
Definition
Furosemide
Term
Thiazide med (1)
Definition
Hydrochlorothiazide
Term
K+ sparring meds (2)
Definition

1.)Spironolactone 

2.) triamterene

Term
what does RAAS do?
Definition
Causes Na+ and water retention which causes an increase in BP
Term
Describe the RAAS in steps
Definition

1.)renin converts angiotensinogen to angiotensin 1

2.)angiotensin 1 is converted to angiotensin 2 by ACE

3.)angiotensin 2 acts on the kidneys to secrete aldosterone

4.) aldosterone increases Na+ reabsorption and decreases urination

Term
ACE-I MOA
Definition
prevents the conversion of angiontensin 1 to angiotensin 2
Term
precautions of ACE-I
Definition
hyperkalemia, renal failure, angioedema, presistent dry cough
Term
ARBs (angiotensin receptor blocker) MOA
Definition
blocks the activity of angiotensin 2
Term
ACE-I meds (1) (*~pril)
Definition
Lisinopril
Term
ARB med (1) (*~sartan)
Definition
Losartan
Term
site of action of loop diuretics
Definition
Loop of henle
Term
site of action of thiazides
Definition
distal convoluted tubule
Term
site of action of K+ sparring diuretics
Definition
distal tubule and collecting ducts
Term
ARBs site of action
Definition
angiotensin 2 receptors
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