Term
|
Definition
IV INFUSION PUMP,
VASODILATOR FOR HYPERTENSIVE EMER AND HF
DURATION 1-10 MIN |
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Term
|
Definition
MOA: dilate peripheral and venous vessels
resulting in reduced PVR result of activation of Guanylyl Cyclase either via release of NO or by direct enzyme stimulation result inc intracellular Cgmp |
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Term
|
Definition
SE: Drug metabolized slowly to THIOCYANATE
fatique weakness
slurred speech,
psychosis,
cyanide accumulation
metabolic acidosis
arrhymias,
excessive hypotension |
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Term
|
Definition
LA IV direct arteriolar vd
one dose (90% albumin bound)
To treat Hypertensive Emer and will cause tachycardia
Similar to Thiazide Diuretics (cross allergenicity) |
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Term
|
Definition
SE: cause CHF, CVA and MI
Hyperglycemia (inhibit insulin reslease)
Hypotension
Sodium and Water retention (minor) |
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Term
|
Definition
Periperal arterial vd
Used for Hypertension Emer and post op
hypertension continous infusion |
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Term
|
Definition
MOA: agonist of Dopamine result in dilation of peripheral arterial arteries
and naturiesis
Conjungation mechanism |
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Term
|
Definition
SE: reflex tachycardia,
headache,
flushing
avoid in glaucoma patients |
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Term
|
Definition
Ganglionic blocker and continuous iv
infusion
Indication for: hypertensive crisis
and dissecting aortic aneurysm |
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Term
|
Definition
SE: DIZZINESS,
HEADACHE,
ANXIETY
TACHYCARDIA
NAUSEA AND VOMITTING
DIARRHEA,
ANEMIA
DYSPNEA, EDEMA, NASAL CONGESTION |
|
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Term
|
Definition
TACHYCARDIA
HYPOTENSION
POSSIBLE CYANIDE TOXICITY |
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Term
| HYPERTENSION EMERGENCY (CRISIS) |
|
Definition
|
|
Term
| HYPERTENSION EMERGENCY (CRISIS) |
|
Definition
Na Nitroprussive
Diazoxide
Fenoldopam
Trimethophan |
|
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Term
| Vasodilator is directly relaxes arteriolar smooth muscle |
|
Definition
| is more potent than A1 blocker |
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Term
| Vasodilator is not effective if used alone why? |
|
Definition
| cause reflex tachycardia that why is administer BBD before given vasodilator |
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Term
|
Definition
Hydralazine HCL
Minodixil
Sodium Nitroprusside
Diazoxide |
|
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Term
|
Definition
Direct arteriolar
Management for CHF patient
Drug may increase renal blood flow
Metabolism by ACETYLATION;
slow acetylators will develop Lupus like syndrome |
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Term
|
Definition
SE:
Lupus Like Syndrome (NEVER CAUSE RENAL DAMAGE)
Reflex tachycardia (add B blockers before)
Fluid retension by stimulating RAAS (add diuretic also)
Headache
Nausea
Leg/ankle edema |
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Term
|
Definition
Indication: severe hypertension refractory to other treatments
Useful in malignant hypertension
Used in patient with renal failure
Alternative to nephectomy
Topical use for ALOPLECIA |
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Term
|
Definition
SE:
Reflex Tachycardia
Fluid retention
Hypertrichosis |
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Term
|
Definition
Benzothiapepines
Dihydropyrines
Phenylalkalines |
|
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Term
|
Definition
Cause smooth muscle relaxation by blocking
the binding of calcium to its receptor
and preventing muscle contraction
This causes decresed peripheral smooth muscle tone, decrease systemic vascular resistance
Result: decreased blood pressure |
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Term
|
Definition
Benzothiazipe: Diltiazem
Phenylalkamine: Verapamil
Dihyropyridines:
amlodipine
nimodipine
nicardipine
nifedipine
bepridil |
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Term
|
Definition
TREAT:
Angina
Hypertension
Dysrhhymias
Migraine headaches |
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|
Term
|
Definition
SE:
Hypotension
Palpitaion
Tachycardia
Constipation
Nausea
Rash
Flushing
Peripheral edema
Dermatitis |
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|
Term
| ANGIOTENSIN II RECEPTOR BLOCKERS: |
|
Definition
WELL TOLERATED
DO NOT CAUSE COUGHING |
|
|
Term
| ANGIOTENSIN II RECEPTOR BLOCKERS: |
|
Definition
MOA: BLOCK THE RECEPTOR THAT RECEIVE
ANGIOTENSIN II
BLOCK VASOCONSTRICTIN AND RELEASE OF ALDOSTERONE |
|
|
Term
| ANGIOTENSIN II RECEPTOR BLOCKERS: |
|
Definition
IOSARTAN
EPOSARTAN
VALSARTAN
IRBESARTAN
CANDESARTAN
TELMISARTAN |
|
|
Term
| ANGIOTENSIN II RECEPTOR BLOCKERS: |
|
Definition
TREAT:
hypertension
CHF
used alone or with other agent such as
diuretic |
|
|
Term
| ANGIOTENSIN II RECEPTOR BLOCKERS: |
|
Definition
SE:
Upper respiratory infection
Headache
Dizziness
Inability to sleep
Dysnea
Heartburn
Nasal Congestion
Back Pain
Fatique |
|
|
Term
| ANGIOTENSIN II RECEPTOR BLOCKERS: |
|
Definition
is given first line in normal person b/w
25-60 years old |
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Term
Angiotensin-Converting Enzyme Inhibitors
(ACE Inhibitors) |
|
Definition
Large group of safe and effective drugs
Often used as first-line agents for CHF
and hypertension
May combined with thiazide diauretic and CCB |
|
|
Term
Angiotensin-Converting Enzyme Inhibitors
(ACE Inhibitors)
RAAS-Renin Angiotensin-Aldosterone Sys |
|
Definition
Prevent ACE thus Preventing the formation of angiotensin II
Also prevent the breakdown of the vasodilating substance, bradykinin |
|
|
Term
Angiotensin-Converting Enzyme Inhibitors
(ACE Inhibitors) |
|
Definition
| Captopril: short half-life, must be dosed more frequently than others |
|
|
Term
| Enalapril: the only ACEI available in oral and parenteral forms |
|
Definition
Angiotensin-Converting Enzyme Inhibitors
(ACE Inhibitors) |
|
|
Term
Angiotensin-Converting Enzyme Inhibitors
(ACE Inhibitors) |
|
Definition
Lisinopril and quinapril
long half-lives, once a day dosing |
|
|
Term
Angiotensin-Converting Enzyme Inhibitors
(ACE Inhibitors) |
|
Definition
Hypertension
Drugs choice fo CHF
Slows progression of left ventricular hypertrophy after an MI
Renal protective effects with diabetic patient |
|
|
Term
Angiotensin-Converting Enzyme Inhibitors
(ACE Inhibitors) |
|
Definition
SE:
Fatigue
Dizziness
Headache
Mood changes
Impaired taste
REMEMBER DRY-NONPRODUCTIVE COUGH, REVERSES WHEN THERAPY IS STOPPED |
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|
Term
Angiotensin-Converting Enzyme Inhibitors
(ACE Inhibitors) |
|
Definition
| FIRST DOSE HYPOTENSIVE EFFECT MAY OCCUR |
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Term
|
Definition
| ALPHA 1 BLOCKER (PERIPHERAL ACTING) |
|
|
Term
|
Definition
| ALPHA 1 BLOCKER (PERIPHERAL ACTING) |
|
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Term
|
Definition
| ALPHA 1 BLOCKER (PERIPHERAL ACTING) |
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|
Term
| ALPHA 1 BLOCKER (PERIPHERAL ACTING) |
|
Definition
| Inhibit release of Norepinephrine and also deplete norepinephrine stores, thus DO NOT stimuulated SNS leading to decreased blood pressure |
|
|
Term
| ALPHA 2 BLOCKER (CENTRAL ACTING ADRENERGIC |
|
Definition
|
|
Term
|
Definition
| ALPHA 2 BLOCKER (CENTRAL ACTING ADRENERGIC |
|
|
Term
|
Definition
| ALPHA 2 BLOCKER (CENTRAL ACTING ADRENERGIC |
|
|
Term
|
Definition
| ALPHA 2 BLOCKER (CENTRAL ACTING ADRENERGIC |
|
|
Term
|
Definition
| USED FOR HYPERTENSION IN PREGNANCY |
|
|
Term
| ALPHA 2 BLOCKER (CENTRAL ACTING ADRENERGIC |
|
Definition
| INDICATION FOR moderate to severe hypertension |
|
|
Term
|
Definition
MOA: A2 agonist in the medulla to reduce SNS tone resulting in reduce BP
Lipid soluble and enters the brain
Administered BID or Patch (7days) |
|
|
Term
|
Definition
SE:
Dry mouth,
Mental Depression
REMEMBER:Rebound life threatening hypertension on rapid withdraw
Fluid retention,
Impotence,
Gynecomastia
Nervousness,
Tachycardia
Headache
Sweating |
|
|
Term
|
Definition
MOA:
REMEMBER A2 AGONIST FALSE TRRANSMITTER ANALOG OF L-DOPA converted to a-methyldopamine and a-methylnorepinepherine parallels synthesis of NE |
|
|
Term
|
Definition
Sedation
Impaired concentration
Nightmares
Parasympathetic Overactivity
Diarrhea
Lupus like syndrome
Impotence,
FALSE positive Coombs test |
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Term
|
Definition
| A1 adrenergic (Peripheral Blockers) |
|
|
Term
|
Definition
| A1 adrenergic (Peripheral Blockers) |
|
|
Term
|
Definition
| A1 adrenergic (Peripheral Blockers) |
|
|
Term
| A1 adrenergic (Peripheral Blockers) |
|
Definition
Reserpine
Guanadrel
Guanethidine |
|
|
Term
|
Definition
Alkaloid roots of Rau Serpentina
1st drugs used in HTN
MOA:
depletes catecholamines from peripheral and central storage vessicles
Must take 2 weeks before efficacy |
|
|
Term
|
Definition
SE:
CNS depression
sedation
EPS or Parkinsonism
Impotence
Orthotic Hypotension
Parasympathetic overactivity brady
Nasal stuff
GI
Weight gain
Urinary
Retension,
Glaucoma
Blurred vision |
|
|
Term
|
Definition
MOA: inhibits release of Catecholamines
at sympathetic nerves, uptake is needed for drug to work, because replaces NE will cause depletion of NE stores |
|
|
Term
|
Definition
| Most potent of all antihypertensive agents due to sympathetic blockade |
|
|
Term
|
Definition
SE:
Explosive Diarrhea
Postural hypotension
Impotence,
NO DROWSINESS because does not enter CNS
Drug not used due to severe SE |
|
|
Term
|
Definition
| NO DROWSINESS because does not enter CNS |
|
|
Term
|
Definition
| BPH BPH BPH and management of severe CHF when used with cardiac glycosides and diuretics |
|
|
Term
| ALPHA 2 BLOCKER (CENTRAL ACTING ADRENERGIC |
|
Definition
Either used alone or with other agents
Usually used after other agents have failed due to side effects
Used for severe Dysmenorrhea, Menopausal flushing, glaucoma |
|
|
Term
|
Definition
| is used in the management of withdrawal symptoms in opioid, crack addict, nicotine dependent persons |
|
|
Term
| Adrenergic agents blockers |
|
Definition
SE:
Dry mouth
Drowsiness
Sedasion
Constipation
Headaches
Sleep Disturbances
Nausea
Rash
Cardiac Disturbances (palpitations |
|
|
Term
| Adrenergic agents blockers |
|
Definition
| HIGH INCIDENCE OF ORTHOSTATIC HYPOTENTION |
|
|
Term
| HYDROCHLOROTHIAZIDE (HCTZ) |
|
Definition
THIAZIDE DIURETIC
POTASSIUM SPARING DIURETICS
MOA: REDUCE BLOOD VOLUME BY DEPLETING NA STORE
SE: hypokalemia |
|
|
Term
| HYDROCHLOROTHIAZIDE (HCTZ) |
|
Definition
| 1st line for hypertension in mild to moderate hypertension |
|
|
Term
|
Definition
|
|
Term
|
Definition
systolic <13O
Diastolic <85 |
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|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
AT2 antagonist
treat hypertension with Nephropathy |
|
|
Term
|
Definition
AT2 antagonist
treat hypertension with Nephropathy |
|
|
Term
|
Definition
AT2 antagonist
treat hypertension with Hear Failure |
|
|
Term
|
Definition
AT2 antagonist
treat hypertension with left ventricular hypertrophy |
|
|
Term
|
Definition
| ACEI for Left ventricular dysfunciton and CHF |
|
|
Term
|
Definition
ACEI for Left ventricular dysfunciton and CHF
and for Diabetic nephropathy |
|
|
Term
|
Definition
| ACEI for Left ventricular dysfunciton and CHF after MI |
|
|
Term
|
Definition
|
|
Term
|
Definition
ACEI with CHF
And also for MI |
|
|
Term
|
Definition
|
|
Term
|
Definition
ACEI to reduce the risk of MI, stroke, and death from CVD
and also for CHF after MI |
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