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Hypersensitivity
Immunology Ch. 13
35
Medical
Undergraduate 1
05/04/2010

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Term
define hypersensitivity
Definition
heightened state of immune response
Term
hs type that may not show manifestation until 24-48 hrs after contact with the ag
Definition
4
Term
cell mediated hs type
Definition
4
Term
igG mediated hs type
Definition
2
Term
igE mediated hs type
Definition
1
Term
igM mediated hs type
Definition
3
Term
which hs types involve complement
Definition
2&3
Term
which hs type involves the release of heparin and histamine from mast cells and basophils
Definition
1
Term
type hs involved in asthma, bee sting, and seafood allergy
Definition
1
Term
hs type involved in HDN and tranfusion rxns
Definition
2
Term
hs type involved in serum sickness and rheumatiod arthritis
Definition
3
Term
hs type involved in contact dermititis like poison ivy or graft vs host
Definition
4
Term
what happens within sm. muscle and vessels when histamine is released
Definition
sm. muscle contracts, vasodilation & increased vascular permability
Term
most common drug involved in type 1 hs
Definition
penicillin
Term
list 4 general areas that present symptoms in immediate hs
Definition
gastrointestinal, respiratory, skin manifestations (hives), anaphalactic shock
Term
what does RAST test for
Definition
it is a qualitative test showing what ag igE is made against
Term
what does RIST test for
Definition
quantitative; measures total amt of igE in pt serum
Term
what type hs has this rxn:
anaphalactic
Definition
1
Term
what type hs has this rxn:
immune complex
Definition
3
Term
what type hs has this rxn:
cytotoxic
Definition
2
Term
what type hs has this rxn:
cell mediated
Definition
4
Term
what type hs has a delayed rxn
Definition
4
Term
which blood groups show the most cellular destruction if incompatibility exists btwn pt and donor?
Definition
ABO
Term
hemolytic transfusion rxns may be immediate (acute) or delayed. List 4 symptoms.
Definition
syonosis, low bp, shortness of breath, rash
Term
what ab causes hdn
Definition
anti-d
Term
what rxn temp is it most important to detect abs and why
Definition
37C bc igG reacts strongest at this temp
Term
what is a disease associated with hdn where bili from lysed rbcs are deposited in tissue like the brain
Definition
kernicterus
Term
what are cold agglutinins
Definition
involved in hemolytic anemia, do not react unless they are at 30C, igM
Term
what hs type do cold agglutinins represent when present
Definition
2
Term
what is AI thrombocytopenic purpura? what causes it?
Definition
auto abs against self plts. cause is unknown
Term
what is goodpastures sydrome? what hs type is it? what organs are targeted?
Definition
ag/ab rxn that affects whole tissues instead of individual cells; type 2; usually targets lungs and kidneys
Term
arthus rxn, serum sickness, and AI diseases are examples of immune complex rxns. what hs type is this?
Definition
3
Term
list 3 tests for type 3 hypersensitivity
Definition
latex agg, fl. staining, measurement of comp levels
Term
tb and pneumonia are associated with what hs type
Definition
4
Term
give 2 tests for detection of type 4 hs
Definition
lymphocyte activation test- measures lymphocyte activity & PPD skin test (TB exposure)
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