Term
| Type I Hypersensitivity Actions |
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Definition
| Immune mediated- Th2 cells induce B cells to produce IgE antibodies which when restimulated by antigen leads to degranulization of mast cells |
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Term
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Definition
| Edema in larynx, hypotension, airway obstruction, vascular dilation- Type I |
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Term
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Definition
| Increase peristalsis- Type I |
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Term
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Definition
| Broncho constriction and mucous secretion- Type I |
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Term
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Definition
| increased mucus secretion (IL-13) |
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Term
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Definition
| Stimulate B-Cell switch to IgE plasma cells |
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Term
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Definition
| released from mast and Th2 cells and activates eosinophils |
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Term
| Type 2 Hypersensitivity Action |
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Definition
| Anti-body mediated reaction- IgG and IgM antibodies against tissues bind neutrophils and macrophages to activate complement system and leads to destruction of tissue |
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Term
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Definition
| Type II against Rh blood group |
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Term
| AI Thrombocytopenic Purpura |
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Definition
| Type II against platelet GpIIB-IIIA---> bleeding |
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Term
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Definition
| Type II against epidermal cell proteins---> bullae |
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Term
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Definition
| Type II against basement membrane of glomerulu and lung alveolar |
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Term
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Definition
| Type II- streptococcal cell wall antigen cross reacts with heart |
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Term
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Definition
| Type II AI against nicotinic ACH receptors |
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Term
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Definition
| Type II against TSH receptors leading to hyperthyroidism |
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Term
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Definition
| Type II AI against gastric parietal cells and loss of intrinsic factor |
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Term
| Type III hypersensitivity actions |
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Definition
| Immune complex deposits in blood vessels mainly, activates complement and phagocytosis |
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Term
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Definition
| Type III- vasculitis, arthrisis, nephritis |
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Term
| Poststreptococcal glomerunephritis |
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Definition
| Type III causing nephritis |
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Term
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Definition
| Type III against Hep. B antigent leading to vasculitis |
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Term
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Definition
Type III- protein antigens given from a serum of another person leads to vasculitis, nephritis, and arthritis.
TX for snake bites and rabies expose |
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Term
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Definition
| Type III- proteins injected into the subcuatneous skin leading to vasculitis of the skin |
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Term
| Treatments for Type II and III |
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Definition
| Plasmapheresis, antibody against CD20 found on B cells |
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Term
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Definition
| CD4 and CD8 T cells activated by antigens, more organ specific than systemic |
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Term
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Definition
| Inflammation due to cytokine release |
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Term
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Definition
| cell lysis and tissue injur |
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Term
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Definition
| activates macrophages and is released due to Th1 |
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Term
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Definition
| Recruits leukocytes and neutrophils |
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Term
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Definition
| Type IV with impared glucose metabolism |
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Term
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Definition
| Type IV due to PTPN22/HLA-DR4 |
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Term
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Definition
| Type IV against myelin CD25 genes |
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Term
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Definition
| Type IV against intestinal microbes- NOD2 gene |
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Term
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Definition
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Term
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Definition
| Type IV granulomatous inflammation |
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Term
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Definition
| Type IV against viral proteins with hepatocyte death |
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Term
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Definition
| Type IV overactivation of T cells of different specificities leading to shock and fever |
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Term
| Tx inflammation of type IV |
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Definition
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Term
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Definition
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Term
| Tx for IV that inhibits T cell response |
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Definition
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